Specialized intercellular communications via tunnelling nanotubes in acute and chronic leukemia

A Allegra, M Di Gioacchino, G Cancemi, M Casciaro… - Cancers, 2022 - mdpi.com
Simple Summary Tunneling nanotubes (TNTs) are cytoplasmic channels which regulate the
contacts between cells and allow the transfer of several elements, including ions …

Tunneling nanotubes: the fuel of tumor progression?

G Pinto, C Brou, C Zurzolo - Trends in cancer, 2020 - cell.com
Tunneling nanotubes (TNTs) are thin membrane tubes connecting remote cells and allowing
the transfer of cellular content. TNTs have been reported in several cancer in vitro, ex vivo …

Cellular and molecular networking within the ecosystem of cancer cell communication via tunneling nanotubes

E Lou, E Zhai, A Sarkari, S Desir, P Wong… - Frontiers in cell and …, 2018 - frontiersin.org
Intercellular communication is vital to the ecosystem of cancer cell organization and
invasion. Identification of key cellular cargo and their varied modes of transport are important …

[HTML][HTML] Tunneling nanotube (TNT) formation is downregulated by cytarabine and NF-κB inhibition in acute myeloid leukemia (AML)

M Omsland, Ø Bruserud, BT Gjertsen, V Andresen - Oncotarget, 2017 - ncbi.nlm.nih.gov
Acute myeloid leukemia (AML) is a bone marrow derived blood cancer where intercellular
communication in the leukemic bone marrow participates in disease development …

Tunneling nanotubes: The intercellular conduits contributing to cancer pathogenesis and its therapy

PK Melwani, BN Pandey - Biochimica et Biophysica Acta (BBA)-Reviews …, 2023 - Elsevier
Tunneling nanotubes (TNTs) are intercellular conduits, which meet the communication
needs of non-adjacent cells situated in the same tissue but at distances up to a few hundred …

Opportunities and challenges in tunneling nanotubes research: how far from clinical application?

X Han, X Wang - International journal of molecular sciences, 2021 - mdpi.com
Tunneling nanotubes (TNTs) are recognized long membrane nanotubes connecting
distance cells. In the last decade, growing evidence has shown that these subcellular …

A Ticket to Ride: The Implications of Direct Intercellular Communication via Tunneling Nanotubes in Peritoneal and Other Invasive Malignancies

E Lou - Frontiers in Oncology, 2020 - frontiersin.org
It is well established that the role of the tumor microenvironment (TME) in cancer
progression and therapeutic resistance is crucial, but many of the underlying mechanisms …

Role of cell‐to‐cell communication in cancer: New features, insights, and directions

EA Eugenin - Cancer Reports, 2019 - Wiley Online Library
The current special issue entitled “Role of tunneling nanotubes (TNTs) in carcinogenesis”
was designed to discuss the role of cell‐to‐cell communication, especially TNTs, in cancer …

Tunneling nanotubes facilitate autophagosome transfer in the leukemic niche

B de Rooij, R Polak, F Stalpers, R Pieters… - Leukemia, 2017 - nature.com
Acute lymphoblastic leukemia (ALL) cells disrupt the healthy bone marrow
microenvironment to create a leukemic niche that is crucial for facilitating leukemogenesis …

Cell communication by tunneling nanotubes: Implications in disease and therapeutic applications

R Mittal, E Karhu, JS Wang, S Delgado… - Journal of cellular …, 2019 - Wiley Online Library
Intercellular communication is essential for the development and maintenance of
multicellular organisms. Tunneling nanotubes (TNTs) are a recently recognized means of …