Duloxetine protected indomethacin-induced gastric mucosal injury by increasing serotonin-dependent RANTES expression and activating PI3K-AKT-VEGF pathway
H Ding, Y Wang, Y Gao, F Ye, K Yao, L Cao… - Toxicology and Applied …, 2024 - Elsevier
Antidepressant duloxetine has been shown protective effect on indomethacin-induced
gastric ulcer, which was escorted by inflammation in the gastric mucosa. Cytokines are the …
gastric ulcer, which was escorted by inflammation in the gastric mucosa. Cytokines are the …
The role of peripheral serotonin and norepinephrine in the gastroprotective effect against stress of duloxetine
H Ding, Y Gao, Y Wang, K Yao, G Wang… - European Journal of …, 2023 - Elsevier
Duloxetine has been shown to produce gastroprotective effect against gastric ulcer induced
by water immersion restraint stress (WIRS) via modulation of NADPH oxidases in the gastric …
by water immersion restraint stress (WIRS) via modulation of NADPH oxidases in the gastric …
DUOX2, a common modulator in preventive effects of monoamine-based antidepressants on water immersion restraint stress-and indomethacin-induced gastric …
L Cao, X Li, R Xu, K Yao, W Yang, H Zhu… - European Journal of …, 2020 - Elsevier
Multiple kinds of monoamine-based antidepressants have been shown prophylactic effects
in experimentally induced gastric ulcer. The loss of redox homeostasis plays a principle role …
in experimentally induced gastric ulcer. The loss of redox homeostasis plays a principle role …
Evaluation of the anti-ulcerogenic activity of the antidepressants duloxetine, amitriptyline, fluoxetine and mirtazapine in different models of experimental gastric ulcer in …
CX Ji, DS Fan, W Li, L Guo, ZL Liang, RM Xu… - European journal of …, 2012 - Elsevier
The effects of acute systemic administration of duloxetine, amitriptyline, mirtazapine and
fluoxetine were compared in experimental models of gastric ulcer in rats. Compared with the …
fluoxetine were compared in experimental models of gastric ulcer in rats. Compared with the …
Rivastigmine ameliorates indomethacin experimentally induced gastric mucosal injury via activating α7nAChR with inhibiting oxidative stress and apoptosis
The current study aimed to investigate the potential ameliorative role of Rivastigmine (RIVA),
the anti‐Alzheimer drug, against the gastric mucosal injury caused by indomethacin (IND) …
the anti‐Alzheimer drug, against the gastric mucosal injury caused by indomethacin (IND) …
[HTML][HTML] 1-Deoxynojirimycin (DNJ) ameliorates indomethacin-induced gastric ulcer in mice by affecting NF-kappaB signaling pathway
X Piao, S Li, X Sui, L Guo, X Liu, H Li, L Gao… - Frontiers in …, 2018 - frontiersin.org
Gastric ulcer (GU) is a main threat to public health. 1-Deoxynojirimycin (DNJ) has
antioxidant and anti-inflammatory properties and may prevent GU but related mechanism …
antioxidant and anti-inflammatory properties and may prevent GU but related mechanism …
Protective effects of perindopril against indomethacin-induced gastric mucosal damage through modulation of DDAH-1/ADMA and ACE-2/ANG-(1-7) signaling …
Indomethacin is a widely used nonsteroidal anti-inflammatory drug; however, its clinical
utility is accompanied by serious adverse reactions including peptic ulcers. The current …
utility is accompanied by serious adverse reactions including peptic ulcers. The current …
Serotonin and histamine mediate gastroprotective effect of fluoxetine against experimentally-induced ulcers in rats
S Salem Sokar, M Elsayed Elsayad… - Journal of …, 2016 - Taylor & Francis
Research in the treatment of gastric ulcer has involved the investigation of new alternatives,
such as anti-depressant drugs. The present study was designed to investigate the …
such as anti-depressant drugs. The present study was designed to investigate the …
Mechanistic perspective of morin protection against ketoprofen-induced gastric mucosal injury: Targeting HMGB1/RAGE/NF-κB, DJ-1/Nrf2/HO-1 and PI3K/mTOR …
HH Arab, MA Saad, AE El-Sahar… - Archives of Biochemistry …, 2020 - Elsevier
Ketoprofen is a widely used NSAID which incurs gastric mucosal damage. The high mobility
group Box 1 (HMGB1) protein is a DNA-binding protein which exerts robust inflammatory …
group Box 1 (HMGB1) protein is a DNA-binding protein which exerts robust inflammatory …
[HTML][HTML] A novel role of irbesartan in gastroprotection against indomethacin-induced gastric injury in rats: targeting DDAH/ADMA and EGFR/ERK signaling
NN Shahin, NF Abdelkader, MM Safar - Scientific reports, 2018 - nature.com
The advent of angiotensin II type 1 receptor blockers (ARBs) as intriguing gastroprotective
candidates and the superior pharmacokinetics and pharmacodynamics displayed by …
candidates and the superior pharmacokinetics and pharmacodynamics displayed by …