Dim light at night shifts microglia to a pro-inflammatory state after cerebral ischemia, altering stroke outcome in mice
Circadian rhythms are endogenous biological cycles that regulate physiology and behavior
and are set to precisely 24-h by light exposure. Light at night (LAN) dysregulates physiology …
and are set to precisely 24-h by light exposure. Light at night (LAN) dysregulates physiology …
Dim light at night exacerbates stroke outcome
Circadian rhythms are endogenous biological cycles that synchronize physiology and
behaviour to promote optimal function. These~ 24‐hr internal rhythms are set to precisely 24 …
behaviour to promote optimal function. These~ 24‐hr internal rhythms are set to precisely 24 …
Dim light at night impairs recovery from global cerebral ischemia
Nighttime lighting is one of the great conveniences of modernization; however, there is
mounting evidence that inopportune light exposure can disrupt physiological and behavioral …
mounting evidence that inopportune light exposure can disrupt physiological and behavioral …
Time Dimension Influences Severity of Stroke and Heightened Immune Response in Mice
Ischemic stroke is caused by obstructed cerebral blood flow, which results in neurological
injury and poor outcomes. Pro-inflammatory signaling from both residential and infiltrating …
injury and poor outcomes. Pro-inflammatory signaling from both residential and infiltrating …
Mice exposed to dim light at night exaggerate inflammatory responses to lipopolysaccharide
The mammalian circadian system regulates many physiological functions including
inflammatory responses. Appropriately timed light information is essential for maintaining …
inflammatory responses. Appropriately timed light information is essential for maintaining …
Environmental circadian disruption increases stroke severity and dysregulates immune response
AM Ramsey, A Stowie… - Journal of biological …, 2020 - journals.sagepub.com
Understanding the health consequences of chronic disruption of circadian rhythms can
contribute to improving prevention strategies for shift workers. Chronic circadian disruption …
contribute to improving prevention strategies for shift workers. Chronic circadian disruption …
Effects of dim light at night in C57BL/6 J mice on recovery after spinal cord injury
JC Aldrich, AR Scheinfeld, SE Lee, KJ Dusenbery… - Experimental …, 2024 - Elsevier
Spinal cord injury (SCI) can cause long-lasting locomotor deficits, pain, and mood disorders.
Anatomical and functional outcomes are exacerbated by inflammation after SCI, which …
Anatomical and functional outcomes are exacerbated by inflammation after SCI, which …
Diurnal differences in immune response in brain, blood and spleen after focal cerebral ischemia in mice
Background: The immune response to acute cerebral ischemia is a major factor in stroke
pathobiology. Circadian biology modulates some aspects of immune response. The goal of …
pathobiology. Circadian biology modulates some aspects of immune response. The goal of …
[HTML][HTML] Preclinical evaluation of circadian rhythm in ischemic stroke outcomes
Stroke is a leading cause of disability and death worldwide. There is evidence that there is a
circadian rhythm in stroke with peak occurrence in the morning (6 to 10 am). However, it is …
circadian rhythm in stroke with peak occurrence in the morning (6 to 10 am). However, it is …
Circadian biology and stroke
EH Lo, GW Albers, M Dichgans, G Donnan, E Esposito… - Stroke, 2021 - Am Heart Assoc
Circadian biology modulates almost all aspects of mammalian physiology, disease, and
response to therapies. Emerging data suggest that circadian biology may significantly affect …
response to therapies. Emerging data suggest that circadian biology may significantly affect …