Dim light at night shifts microglia to a pro-inflammatory state after cerebral ischemia, altering stroke outcome in mice

JA Liu, WH Walker II, OH Meléndez-Fernández… - Experimental …, 2024 - Elsevier
Circadian rhythms are endogenous biological cycles that regulate physiology and behavior
and are set to precisely 24-h by light exposure. Light at night (LAN) dysregulates physiology …

Dim light at night exacerbates stroke outcome

ZM Weil, LK Fonken, WH Walker… - European Journal of …, 2020 - Wiley Online Library
Circadian rhythms are endogenous biological cycles that synchronize physiology and
behaviour to promote optimal function. These~ 24‐hr internal rhythms are set to precisely 24 …

Dim light at night impairs recovery from global cerebral ischemia

LK Fonken, TA Bedrosian, N Zhang, ZM Weil… - Experimental …, 2019 - Elsevier
Nighttime lighting is one of the great conveniences of modernization; however, there is
mounting evidence that inopportune light exposure can disrupt physiological and behavioral …

Time Dimension Influences Severity of Stroke and Heightened Immune Response in Mice

PK Kamat, MB Khan, S Siddiqui, D Williams… - Translational Stroke …, 2023 - Springer
Ischemic stroke is caused by obstructed cerebral blood flow, which results in neurological
injury and poor outcomes. Pro-inflammatory signaling from both residential and infiltrating …

Mice exposed to dim light at night exaggerate inflammatory responses to lipopolysaccharide

LK Fonken, ZM Weil, RJ Nelson - Brain, Behavior, and Immunity, 2013 - Elsevier
The mammalian circadian system regulates many physiological functions including
inflammatory responses. Appropriately timed light information is essential for maintaining …

Environmental circadian disruption increases stroke severity and dysregulates immune response

AM Ramsey, A Stowie… - Journal of biological …, 2020 - journals.sagepub.com
Understanding the health consequences of chronic disruption of circadian rhythms can
contribute to improving prevention strategies for shift workers. Chronic circadian disruption …

Effects of dim light at night in C57BL/6 J mice on recovery after spinal cord injury

JC Aldrich, AR Scheinfeld, SE Lee, KJ Dusenbery… - Experimental …, 2024 - Elsevier
Spinal cord injury (SCI) can cause long-lasting locomotor deficits, pain, and mood disorders.
Anatomical and functional outcomes are exacerbated by inflammation after SCI, which …

Diurnal differences in immune response in brain, blood and spleen after focal cerebral ischemia in mice

E Esposito, F Zhang, JH Park, ET Mandeville, W Li… - Stroke, 2022 - Am Heart Assoc
Background: The immune response to acute cerebral ischemia is a major factor in stroke
pathobiology. Circadian biology modulates some aspects of immune response. The goal of …

[HTML][HTML] Preclinical evaluation of circadian rhythm in ischemic stroke outcomes

PK Kamat, MB Khan, K Wood, S Siddiqui… - Conditioning …, 2021 - ncbi.nlm.nih.gov
Stroke is a leading cause of disability and death worldwide. There is evidence that there is a
circadian rhythm in stroke with peak occurrence in the morning (6 to 10 am). However, it is …

Circadian biology and stroke

EH Lo, GW Albers, M Dichgans, G Donnan, E Esposito… - Stroke, 2021 - Am Heart Assoc
Circadian biology modulates almost all aspects of mammalian physiology, disease, and
response to therapies. Emerging data suggest that circadian biology may significantly affect …