Tumor Spectrum in ARF-deficient Mice
T Kamijo, S Bodner, E van de Kamp, DH Randle… - Cancer research, 1999 - AACR
The p19ARF product of the INK4a/ARF locus is induced in response to potentially oncogenic
hyperproliferative signals and activates p53 by interfering with its negative regulator, Mdm2 …
hyperproliferative signals and activates p53 by interfering with its negative regulator, Mdm2 …
p53-Dependent and-independent functions of the Arf tumor suppressor
CJ Sherr, D Bertwistle, W Den Besten… - Cold Spring Harbor …, 2005 - symposium.cshlp.org
Abstract The Ink4a-Arf locus encodes two closely wedded tumor suppressor proteins (p16
Ink4a and p19 Arf) that inhibit cell proliferationby activating Rb and p53, respectively. With …
Ink4a and p19 Arf) that inhibit cell proliferationby activating Rb and p53, respectively. With …
Arf induces p53-dependent and-independent antiproliferative genes
ML Kuo, EJ Duncavage, R Mathew, W Den Besten… - Cancer Research, 2003 - AACR
The tumor suppressor p19Arf (p14ARF in humans), encoded by the Ink4a/Arf locus, is
mutated, deleted, or silenced in many forms of cancer. p19Arf induces growth arrest by …
mutated, deleted, or silenced in many forms of cancer. p19Arf induces growth arrest by …
Loss of the ARF tumor suppressor reverses premature replicative arrest but not radiation hypersensitivity arising from disabled atm function
T Kamijo, E van de Kamp, MJ Chong, F Zindy, JA Diehl… - Cancer research, 1999 - AACR
The alternative reading frame product (p19ARF) of the mouse INK4a/ARF locus is induced
by oncoproteins such as Myc and E1A as part of a checkpoint response that limits cell cycle …
by oncoproteins such as Myc and E1A as part of a checkpoint response that limits cell cycle …
p14ARF induces G2 arrest and apoptosis independently of p53 leading to regression of tumours established in nude mice
B Eymin, C Leduc, JL Coll, E Brambilla, S Gazzeri - Oncogene, 2003 - nature.com
Until recently, the ability of ARF (human p14 ARF, murine p19 ARF) tumour-suppressor
protein, encoded by the INK4A/ARF locus, to inhibit cell growth in response to various stimuli …
protein, encoded by the INK4A/ARF locus, to inhibit cell growth in response to various stimuli …
The INK4a/ARF locus in murine tumorigenesis
M Serrano - Carcinogenesis, 2000 - academic.oup.com
The INK4a/ARF locus is regarded as one of the most important anti-tumoral defenses that
mammalian organisms possess. The characterization of its two gene products, p16INK4a …
mammalian organisms possess. The characterization of its two gene products, p16INK4a …
Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2
T Kamijo, JD Weber, G Zambetti… - Proceedings of the …, 1998 - National Acad Sciences
The INK4a-ARF locus encodes two proteins, p16INK4a and p19ARF, that restrain cell
growth by affecting the functions of the retinoblastoma protein and p53, respectively …
growth by affecting the functions of the retinoblastoma protein and p53, respectively …
INK4a/ARF: a multifunctional tumor suppressor locus
NE Sharpless - … Research/Fundamental and Molecular Mechanisms of …, 2005 - Elsevier
The INK4a/ARF locus encodes two physically linked tumor suppressor proteins, p16INK4a
and ARF, which regulate the RB and p53 pathways, respectively. The unusual genomic …
and ARF, which regulate the RB and p53 pathways, respectively. The unusual genomic …
[HTML][HTML] ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
The INK4a-ARF locus encodes two unrelated proteins that both function in tumor
suppression. p16 INK4a binds to and inhibits the activity of CDK4 and CDK6, and ARF …
suppression. p16 INK4a binds to and inhibits the activity of CDK4 and CDK6, and ARF …
Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus
S Llanos, PA Clark, J Rowe, G Peters - Nature cell biology, 2001 - nature.com
The alternative product of the human INK4a/ARF locus, p14 ARF, has the potential to act as
a tumour suppressor by binding to and inhibiting the p53 antagonist MDM2. Current models …
a tumour suppressor by binding to and inhibiting the p53 antagonist MDM2. Current models …