Insulin resistance,“a relative impairment in the ability of insulin to exert its effects on glucose,
protein and lipid metabolism in target tissues,” has many detrimental effects on metabolism …

The obesity pandemic increases the prevalence of type 2 diabetes (DM2). DM2 develops
when pancreatic β-cells fail and cannot compensate for the decrease in insulin sensitivity …

Background The prevalence of type 2 diabetes is rapidly increasing world-wide and insulin
resistance is central to the aetiology of this disease. The biology underpinning the …

Type 2 diabetes mellitus (T2DM) has been related to alterations of oxidative metabolism in
insulin-responsive tissues. Overt T2DM can present with acquired or inherited reductions of …

Insulin resistance is a key defect associated with obesity and type-2 diabetes. The precise
factors that lead to insulin resistance have not been elucidated fully, but there is a strong …

Abundant evidence has been accumulated to suggest that mitochondrial dysfunction is
associated with type 2 diabetes. Research findings from this and other laboratories have …

Mitochondrial function refers to a broad spectrum of features such as resting mitochondrial
activity,(sub) maximal oxidative phosphorylation capacity (OXPHOS), and mitochondrial …

As a major site of glucose uptake following a meal, skeletal muscle has an important role in
whole-body glucose metabolism. Evidence in humans and animal models of insulin …

Insulin resistance is characteristic of obesity, type 2 diabetes, and components of the
cardiometabolic syndrome, including hypertension and dyslipidemia, that collectively …

Mitochondrial dysfunction has been implicated in the development of insulin resistance (IR);
however, a large variety of association and intervention studies as well as genetic …