[HTML][HTML] CD95/Fas, non-apoptotic signaling pathways, and kinases

M Le Gallo, A Poissonnier, P Blanco… - Frontiers in …, 2017 - frontiersin.org
Endothelial cells lining new blood vessels that develop during inflammatory disorders or
cancers act as doors that either allow or block access to the tumor or inflamed organ. Recent …

Soluble CD95L in cancers and chronic inflammatory disorders, a new therapeutic target?

K Kurma, A Boizard-Moracchini, G Galli, M Jean… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Although CD95L (also known as FasL) is still predominantly considered as a death ligand
that induces apoptosis in infected and transformed cells, substantial evidence indicate that it …

CD95-mediated cell signaling in cancer: mutations and post-translational modulations

S Tauzin, L Debure, JF Moreau, P Legembre - Cellular and molecular life …, 2012 - Springer
Apoptosis has emerged as a fundamental process important in tissue homeostasis, immune
response, and during development. CD95 (also known as Fas), a member of the tumor …

CD95/Fas and metastatic disease: What does not kill you makes you stronger

JP Guégan, C Ginestier, E Charafe-Jauffret… - Seminars in cancer …, 2020 - Elsevier
CD95 (also known as Fas) is the prototype of death receptors; however, evidence suggests
that this receptor mainly implements non-apoptotic signaling pathways such as NF-κB …

The CD95/CD95L signaling pathway: a role in carcinogenesis

A Fouqué, L Debure, P Legembre - … et Biophysica Acta (BBA)-Reviews on …, 2014 - Elsevier
Apoptosis is a fundamental process that contributes to tissue homeostasis, immune
responses, and development. The receptor CD95, also called Fas, is a member of the tumor …

CD95 (Fas) and CD95L (FasL)-mediated non-canonical signaling pathways

L Haymour, M Jean, C Smulski, P Legembre - Biochimica et Biophysica …, 2023 - Elsevier
Although the interaction of CD95L (also known as FasL) with its so-called death receptor
CD95 (Fas) induces an apoptotic signal responsible for the elimination of infected and …

[HTML][HTML] Therapeutic approaches targeting CD95L/CD95 signaling in cancer and autoimmune diseases

V Risso, E Lafont, M Le Gallo - Cell death & disease, 2022 - nature.com
Cell death plays a pivotal role in the maintenance of tissue homeostasis. Key players in the
controlled induction of cell death are the Death Receptors (DR). CD95 is a prototypic DR …

[HTML][HTML] Role of metalloproteases in the CD95 signaling pathways

L Devel, N Guedeney, S Bregant… - Frontiers in …, 2022 - frontiersin.org
CD95L (also known as FasL or CD178) is a member of the tumor necrosis family (TNF)
superfamily. Although this transmembrane ligand has been mainly considered as a potent …

CD95L and anti-tumor immune response: current understanding and new evidence

DM Richards, C Merz, C Gieffers… - Cancer management …, 2021 - Taylor & Francis
The ability of FasL/CD95L to induce apoptosis in various Fas/CD95-expressing cells has
been described in the context of hematopoiesis or thymic elimination of self-reactive T cells …

Modulation of CD95-mediated signaling by post-translational modifications: towards understanding CD95 signaling networks

K Seyrek, IN Lavrik - Apoptosis, 2019 - Springer
CD95 is a member of the death receptor family and is well-known to promote apoptosis.
However, accumulating evidence indicates that in some context CD95 has not only the …