A PATHOLOGICAL hallmark of Alzheimer's disease is the deposition of amyloid fibrils in the
brain. The principal component of the amyloid fibril is β/A4 protein1, 2, which is derived from …

The part that genetics plays in the origin of Alzheimer's disease (AD) is a complex problem
that is only now, in the last few years, beginning to be understood. Progress in the study of …

Alzheimer disease was transmitted in a pattern consistent with an autosomal dominant trait
in three families. This brings to 50 the number of such families reported. In one of our …

Following reports of mutations of codon 717 in exon 17 of the amyloid precursor protein
(APP) gene in early–onset familial Alzheimer's disease, we screened exon 17 for new …

Mutations in three different genes on chromosomes 1, 14, and 21 cause autosomal
dominant forms of familial Alzheimer's disease (FAD). Most result in an early‐onset …

The gene, encoding the A4 peptide found in the amyloid core of senile plaques isolated from
the cerebral cortex of patients with Alzheimer's disease, produces at least three precursors …

THERE are many causes of the clinical state dementia. Excluding those patients with
tumours, infection or vascular disease, there remains a large group1 whose brains are …

Comments on an article by Kawabata et al, in the December, 12, 1991 issue ofNature,'and
suggests that it will give added momentum to the molecular assault on the underlying …