Topoisomerase I (topo I) is a ubiquitous DNA-cleaving enzyme and an important therapeutic
target in cancer chemotherapy. Camptothecins (CPTs) reversibly trap topo I in covalent …

Topoisomerase I is a ubiquitous DNA-cleaving enzyme and an important therapeutic target
in cancer chemotherapy for camptothecins (CPTs). These drugs stimulate DNA cleavage by …

To achieve a sequence-specific DNA cleavage by topoisomerase I, derivatives of the
antitumor drug camptothecin have been covalently linked to triple helix-forming …

Topoisomerase I (Top1) activities are sensitive to various endogenous base modifications,
and anticancer drugs including the natural alkaloid camptothecin. Here, we show that triple …

The sequence-specific targeting of duplex DNA using triple helix-forming oligonucleotides
(TFOs) has attracted broad attention. 1 Currently, all such attempts to target DNA have used …

Triple helix‐forming oligonucleotides covalently linked to topoisomerase I inhibitors, in
particular the antitumor agent camptothecin, trigger topoisomerase I‐mediated DNA …

Human topoisomerase II (topo II) is the cellular target for a number of widely used antitumor
agents, such as etoposide (VP16). These agents 'poison'the enzyme and induce it to …

Camptothecin (CPT, I), a unique pentacyclic quinoline alkaloid originally isolated from a
native tree of Tibet and China called Camptotheca acuminata in latin and Xi Shu in Chinese …

Camptothecins constitute a novel class of chemotherapeutics that selectively target DNA
topoisomerase I (Top1) by reversibly stabilizing a covalent enzyme-DNA intermediate. This …

There is considerable interest in the development of sequence-selective DNA drugs.
Chemical agents able to interfere with DNA topoisomerases-essential nuclear enzymes-are …