[HTML][HTML] Good cop, bad cop: The different roles of SRPKs
SR Protein Kinases (SRPKs), discovered approximately 30 years ago, are widely known as
splice factor kinases due to their decisive involvement in the regulation of various steps of …
splice factor kinases due to their decisive involvement in the regulation of various steps of …
[HTML][HTML] Serine-Arginine Protein Kinase 1 (SRPK1): A systematic review of its multimodal role in oncogenesis
WP Duggan, E O'Connell, JHM Prehn… - Molecular and Cellular …, 2022 - Springer
Alternative splicing is implicated in each of the hallmarks of cancer, and is mechanised by
various splicing factors. Serine-Arginine Protein Kinase 1 (SRPK1) is an enzyme which …
various splicing factors. Serine-Arginine Protein Kinase 1 (SRPK1) is an enzyme which …
[HTML][HTML] Serine-arginine protein kinase 1 (SRPK1) is elevated in gastric cancer and plays oncogenic functions
X Xu, Y Wei, S Wang, M Luo, H Zeng - Oncotarget, 2017 - ncbi.nlm.nih.gov
Serine-arginine protein kinase 1 (SRPK1) phosphorylates proteins involved in the regulation
of several mRNA processing pathways including alternative splicing. SRPK1 has been …
of several mRNA processing pathways including alternative splicing. SRPK1 has been …
Expression of SRPK1 in gliomas and its role in glioma cell lines viability
Among factors regulating the splicing of major importance is serine/arginine protein kinase 1
(SRPK1) that phosphorylates SR splicing factors. SRPK1 is expressed in the mammalian …
(SRPK1) that phosphorylates SR splicing factors. SRPK1 is expressed in the mammalian …
[HTML][HTML] Serine-arginine protein kinase 1 (SRPK1) as a prognostic factor and potential therapeutic target in cancer: current evidence and future perspectives
Cancer, a heterogeneous disease composed of tumor cells and microenvironment, is driven
by deregulated processes such as increased proliferation, invasion, metastasis …
by deregulated processes such as increased proliferation, invasion, metastasis …
SRPK1 is a poor prognostic indicator and a novel potential therapeutic target for human colorectal cancer
N Yi, M Xiao, F Jiang, Z Liu, W Ni, C Lu… - OncoTargets and …, 2018 - Taylor & Francis
Background Serine/arginine protein kinase 1 (SRPK1) is a protein kinase that belongs to the
serine/arginine-rich domain family of splicing factors which are essential for splice-site …
serine/arginine-rich domain family of splicing factors which are essential for splice-site …
CRISPR/Cas9‐mediated double knockout of SRPK1 and SRPK2 in a nasopharyngeal carcinoma cell line
P Prattapong, C Ngernsombat, S Aimjongjun… - Cancer …, 2020 - Wiley Online Library
Background Serine‐arginine protein kinase (SRPK) is a regulator of alternative splicing
events via phosphorylation of splicing factor proteins. Oncogenic roles of SRPK1 and …
events via phosphorylation of splicing factor proteins. Oncogenic roles of SRPK1 and …
Akt-ing up on SRPK1: oncogene or tumor suppressor?
In this issue of Molecular Cell, Wang et al.(2014) report that the splicing kinase SRPK1 can
function as both an oncogene and a tumor suppressor by modulating the activation state of …
function as both an oncogene and a tumor suppressor by modulating the activation state of …
Targeting the RNA splicing machinery as a novel treatment strategy for pancreatic carcinoma
GM Hayes, PE Carrigan, AM Beck, LJ Miller - Cancer Research, 2006 - AACR
Aberrant patterns of pre-mRNA splicing have been established for many human
malignancies, yet the mechanisms responsible for these tumor-specific changes remain …
malignancies, yet the mechanisms responsible for these tumor-specific changes remain …