Adaptive responses of neuronal mitochondria to bioenergetic challenges: Roles in neuroplasticity and disease resistance
SM Raefsky, MP Mattson - Free Radical Biology and Medicine, 2017 - Elsevier
An important concept in neurobiology is “neurons that fire together, wire together” which
means that the formation and maintenance of synapses is promoted by activation of those …
means that the formation and maintenance of synapses is promoted by activation of those …
Neuronal metabolic rewiring promotes resilience to neurodegeneration caused by mitochondrial dysfunction
E Motori, I Atanassov, SMV Kochan… - Science …, 2020 - science.org
Neurodegeneration in mitochondrial disorders is considered irreversible because of limited
metabolic plasticity in neurons, yet the cell-autonomous implications of mitochondrial …
metabolic plasticity in neurons, yet the cell-autonomous implications of mitochondrial …
Mitochondria and neuroplasticity
A Cheng, Y Hou, MP Mattson - ASN neuro, 2010 - journals.sagepub.com
The production of neurons from neural progenitor cells, the growth of axons and dendrites
and the formation and reorganization of synapses are examples of neuroplasticity. These …
and the formation and reorganization of synapses are examples of neuroplasticity. These …
[HTML][HTML] Programming axonal mitochondrial maintenance and bioenergetics in neurodegeneration and regeneration
Mitochondria generate ATP essential for neuronal growth, function, and regeneration. Due
to their polarized structures, neurons face exceptional challenges to deliver mitochondria to …
to their polarized structures, neurons face exceptional challenges to deliver mitochondria to …
Mitochondrial regulation of neuronal plasticity
MP Mattson - Neurochemical research, 2007 - Springer
The structure and function of neurons is dynamic during development and in adaptive
responses of the adult nervous system to environmental demands. The mechanisms that …
responses of the adult nervous system to environmental demands. The mechanisms that …
Mitochondria and the brain: bioenergetics and beyond
The view of mitochondria acting solely as a powerhouse of the cell is no longer accurate.
Besides cell bioenergetics, primary targets of mitochondrial studies include their interplay …
Besides cell bioenergetics, primary targets of mitochondrial studies include their interplay …
Mitochondria, energy, and metabolism in neuronal health and disease
Mitochondria are associated with various cellular activities critical to homeostasis,
particularly in the nervous system. The plastic architecture of the mitochondrial network and …
particularly in the nervous system. The plastic architecture of the mitochondrial network and …
Mitochondrial dynamics in neuronal injury, development and plasticity
Mitochondria fulfill numerous cellular functions including ATP production, Ca2+ buffering,
neurotransmitter synthesis and degradation, ROS production and sequestration, apoptosis …
neurotransmitter synthesis and degradation, ROS production and sequestration, apoptosis …
Mitochondrial inhibition and oxidative stress: reciprocating players in neurodegeneration
GD Zeevalk, LP Bernard, C Song, M Gluck… - Antioxidants & redox …, 2005 - liebertpub.com
Although the etiology for many neurodegenerative diseases is unknown, the common
findings of mitochondrial defects and oxidative damage posit these events as contributing …
findings of mitochondrial defects and oxidative damage posit these events as contributing …
Mitochondrial energy metabolism and redox signaling in brain aging and neurodegeneration
Significance: The mitochondrial energy-transducing capacity is essential for the
maintenance of neuronal function, and the impairment of energy metabolism and redox …
maintenance of neuronal function, and the impairment of energy metabolism and redox …