Combining markers into haplotypes can improve population structure inference
LM Gattepaille, M Jakobsson - Genetics, 2012 - academic.oup.com
High-throughput genotyping and sequencing technologies can generate dense sets of
genetic markers for large numbers of individuals. For most species, these data will contain …
genetic markers for large numbers of individuals. For most species, these data will contain …
Population structure with localized haplotype clusters
SR Browning, BS Weir - Genetics, 2010 - academic.oup.com
We propose a multilocus version of F ST and a measure of haplotype diversity using
localized haplotype clusters. Specifically, we use haplotype clusters identified with BEAGLE …
localized haplotype clusters. Specifically, we use haplotype clusters identified with BEAGLE …
Understanding the accuracy of statistical haplotype inference with sequence data of known phase
Statistical methods for haplotype inference from multi‐site genotypes of unrelated
individuals have important application in association studies and population genetics …
individuals have important application in association studies and population genetics …
Detecting disease associations due to linkage disequilibrium using haplotype tags: a class of tests and the determinants of statistical power
JM Chapman, JD Cooper, JA Todd, DG Clayton - Human heredity, 2003 - karger.com
In the 'indirect'method of detecting genetic associations between a trait and a DNA variant,
we type several markers in a gene or chromosome region of linkage disequilibrium. If there …
we type several markers in a gene or chromosome region of linkage disequilibrium. If there …
Efficient selective screening of haplotype tag SNPs
X Ke, LR Cardon - Bioinformatics, 2003 - academic.oup.com
Abstract: Haplotypes defined by common single nucleotide polymorphisms (SNPs) have
important implications for mapping of disease genes and human traits. Often only a small …
important implications for mapping of disease genes and human traits. Often only a small …
[HTML][HTML] Comparisons of two methods for haplotype reconstruction and haplotype frequency estimation from population data
Haplotype reconstruction is an important issue, both in population genetics and in the
identification of complex disease genes. Stephens et al.(2001) proposed a new statistical …
identification of complex disease genes. Stephens et al.(2001) proposed a new statistical …
Use of unphased multilocus genotype data in indirect association studies
D Clayton, J Chapman, J Cooper - Genetic Epidemiology: The …, 2004 - Wiley Online Library
It is usually assumed that detection of a disease susceptability gene via marker
polymorphisms in linkage disequilibrium with it is facilitated by consideration of marker …
polymorphisms in linkage disequilibrium with it is facilitated by consideration of marker …
The portability of tagSNPs across populations: a worldwide survey
A González-Neira, X Ke, O Lao, F Calafell… - Genome …, 2006 - genome.cshlp.org
In the search for common genetic variants that contribute to prevalent human diseases,
patterns of linkage disequilibrium (LD) among linked markers should be considered when …
patterns of linkage disequilibrium (LD) among linked markers should be considered when …
[HTML][HTML] Methods for the selection of tagging SNPs: a comparison of tagging efficiency and performance
K Ding, IJ Kullo - European Journal of Human Genetics, 2007 - nature.com
There is great interest in the use of tagging single nucleotide polymorphisms (tSNPs) to
facilitate association studies of complex diseases. This is based on the premise that a …
facilitate association studies of complex diseases. This is based on the premise that a …
[HTML][HTML] Matching strategies for genetic association studies in structured populations
DA Hinds, RP Stokowski, N Patil, K Konvicka… - The American Journal of …, 2004 - cell.com
Association studies in populations that are genetically heterogeneous can yield large
numbers of spurious associations if population subgroups are unequally represented …
numbers of spurious associations if population subgroups are unequally represented …