We consider two-stage case-control designs for testing associations between single
nucleotide polymorphisms (SNPs) and disease, in which a subsample of subjects is used to …

The Haplotype Map (HapMap) project recently generated genotype data for more than 1
million single-nucleotide polymorphisms (SNPs) in four population samples. The main …

This paper reviews the theoretical basis for single nucleotide polymorphism (SNP) tagging
and considers the use of current software made freely available for this task. A distinction …

We propose a new multimarker test for family‐based studies in candidate genes. We use
simulations under different genetic models to assess the performance of competing testing …

Ever since Risch and Merikangas 1 introduced the concept of whole-genome association
using single-nucleotide polymorphisms (SNPs) in 1996, the question of how many SNPs …

Genotyping costs still preclude analysis of a comprehensive SNP map in thousands of
individual subjects in the search for disease susceptibility loci. Allele frequency estimation in …

Improvements in technology have made it possible to conduct genome-wide association
mapping at costs within reach of academic investigators, and experiments are currently …

Whole genome association studies are generating data sets with hundreds of thousands of
markers genotyped on thousands of cases and controls. We show that whole genome …