LncRNA-Meg3 promotes Nlrp3-mediated microglial inflammation by targeting miR-7a-5p

J Meng, T Ding, Y Chen, T Long, Q Xu, W Lian… - International …, 2021 - Elsevier
Recent studies have identified neuroinflammation as a significant contributor to the
pathological process of traumatic brain injury (TBI) and as a potentially effective target for …

miRNA-20b inhibits cerebral ischemia-induced inflammation through targeting NLRP3

J Zhao, H Wang, L Dong, S Sun… - … Journal of Molecular …, 2019 - spandidos-publications.com
The present study was designed to investigate the role of microRNA (miRNA)‑20b in the
inflammatory response during cerebral ischemia and the underlying mechanism following …

MicroRNA let-7c-5p improves neurological outcomes in a murine model of traumatic brain injury by suppressing neuroinflammation and regulating microglial …

J Lv, Y Zeng, Y Qian, J Dong, Z Zhang, J Zhang - Brain research, 2018 - Elsevier
MicroRNAs (miRNAs) are a class of non-coding small RNAs that regulate the expression of
target genes. They derive from pre-miRNAs that are enzymatically processed by dicer to∼ …

MicroRNA miR-27b-3p regulate microglial inflammation response and cell apoptosis by inhibiting A20 (TNF-α-induced protein 3)

L Li, C Qi, Y Liu, Y Shen, X Zhao, H Qin, Y Zhang… - …, 2021 - Taylor & Francis
Inflammatory reaction exerts a pivotal role in secondary damage after cerebral hemorrhage
and spinal cord injury. miRNAs can both promote and inhibit inflammatory actions among …

LncRNA H19 regulates lipopolysaccharide (LPS)-induced apoptosis and inflammation of BV2 microglia cells through targeting miR-325-3p/NEUROD4 axis

E Gu, W Pan, K Chen, Z Zheng, G Chen… - Journal of Molecular …, 2021 - Springer
Spinal cord injury (SCI) is a devastating traumatic event worldwide. Work from the past
decade has highlighted the key involvement of long non-coding RNAs (lncRNAs) in SCI …

Blocking the LncRNA MALAT1/miR-224-5p/NLRP3 axis inhibits the hippocampal inflammatory response in T2DM with OSA

P Du, J Wang, Y Han, J Feng - Frontiers in Cellular Neuroscience, 2020 - frontiersin.org
Studies have shown that diabetes can cause cognitive dysfunction, and cognitive
dysfunction in patients with diabetes combined with obstructive sleep apnea (OSA) is more …

MicroRNA-374a-5p inhibits neuroinflammation in neonatal hypoxic-ischemic encephalopathy via regulating NLRP3 inflammasome targeted Smad6

Z Chen, Y Hu, R Lu, M Ge, L Zhang - Life sciences, 2020 - Elsevier
Aims Neonatal hypoxic-ischemic encephalopathy (HIE) is still an important cause of
neurological dysfunction. At present, there is no reliable biochemical index in clinical …

MicroRNA-182-5p attenuates cerebral ischemia-reperfusion injury by targeting Toll-like receptor 4

J Wang, Z Xu, X Chen, Y Li, C Chen, C Wang… - Biochemical and …, 2018 - Elsevier
Cerebral ischemia-reperfusion-induced microglial activation causes neuronal death through
the release of inflammatory cytokines. Increasing evidence suggests that microRNAs …

LncRNA MEG3 regulates microglial polarization through KLF4 to affect cerebral ischemia-reperfusion injury

T Li, Y Luo, P Zhang, S Guo, H Sun… - Journal of Applied …, 2020 - journals.physiology.org
This study aimed to explore whether long noncoding RNA (lncRNA) maternally expressed
gene 3 (MEG3) affects the polarization of microglia in cerebral ischemia-reperfusion (I/R) …

[HTML][HTML] lncRNA MEG3 aggravated neuropathic pain and astrocyte overaction through mediating miR-130a-5p/CXCL12/CXCR4 axis

J Dong, R Xia, Z Zhang, C Xu - Aging (Albany NY), 2021 - ncbi.nlm.nih.gov
Objective: Long non-coding RNAs (lncRNAs) exert a critical function in mediating
neuropathic pain (NP). MEG3, a novel lncRNA, contributes to astrocyte activation and …