Histone deacetylases (HDACs) regulate gene transcription by catalyzing the removal of
acetyl groups from key lysine residues in nucleosomal histones and via the recruitment of …

Increased expression of vascular cell adhesion molecule (VCAM)-1 on the activated arterial
endothelial cell (EC) surface critically contributes to atherosclerosis which may in part be …

Abstract Aims Angiotensin II (Ang II) causes vascular inflammation, leading to vascular
endothelial cell dysfunction, and is associated with the development of cardiovascular …

Abstract Histone deacetylase 11 (HDAC11), a sole member of the class IV HDAC subfamily,
participates in various cardiovascular diseases. Recent evidence showed that pyroptosis …

Background—Angiotensin II (Ang II) induces the phenotypic modulation and hypertrophy of
vascular smooth muscle cells (VSMCs), which is implicated in the pathogenesis of …

Small molecule histone deacetylase (HDAC) inhibitors block adverse cardiac remodeling in
animal models of heart failure. The efficacious compounds target class I, class IIb and, to a …

Endothelial cell (EC), consisting of the innermost cellular layer of all types of vessels, is not
only a barrier composer but also performing multiple functions in physiological processes. It …

Background/Aims: Aberrant expression of components of the matrix metalloproteinase
(MMP) enzyme system is implicated in abdominal aortic aneurysm (AAA) formation. We …

Objective: Histone deacetylase (HDAC) inhibitors have been reported to improve essential
and secondary hypertension. However, the specific HDAC that might serve as a therapeutic …

Class I and II histone deacetylases (HDACs) play vital roles in regulating cardiac
development, morphogenesis, and hypertrophic responses. Although the roles of Hdac1 …