Endocrine cells within the pancreatic islets of Langerhans are heterogeneous in terms of
transcriptional profile, protein expression and the regulation of hormone release. Even …

Human islets exhibit distinct islet architecture with intermingled alpha-and beta-cells
particularly in large islets. In this study, we quantitatively examined pathological changes of …

Pancreatic β-cells play a pivotal role in maintaining normoglycemia. Recent studies have
revealed that the β-cell is not a homogeneous cell population but, rather, is heterogeneous …

The endocrine pancreas consists of highly vascularized and innervated endocrine mini-
organs—the islets of Langerhans. These contain multiple types of hormone-producing cells …

Insulin-secreting β-cells are heterogeneous in their regulation of hormone release. While
long known, recent technological advances and new markers have allowed the identification …

Metabolic homeostasis in mammals is tightly regulated by the complementary actions of
insulin and glucagon. The secretion of these hormones from pancreatic β-cells and α-cells …

The islets of Langerhans or pancreatic islets are pivotal in the control of blood glucose and
are complex microorgans embedded within the larger volume of the exocrine pancreas …

Although β-cell heterogeneity was discovered more than 50 years ago, the underlying
principles have been explored only during the past decade. Islet-cell heterogeneity arises …

Cells in different tissues, including endocrine cells in the pancreas, live in complex
microenvironments that are rich in cellular and acellular components. Intricate interactions …

The pancreatic islet is a complex mini organ composed of a variety of endocrine cells and
their support cells, which together tightly control blood glucose homeostasis. Changes in …