Abstract 5α-Reductases are crucial enzymes involved in the biosynthesis of
dihydrotestosterone, the most potent natural androgen. To date, three types of 5α …

According to current knowledge, two steroid 5α-reductases, designated type 1 (SRD5A1)
and type 2 (SRD5A2), are present in all species examined to date. These isozymes play a …

BACKGROUND A third isozyme of human 5α‐steroid reductase, 5α‐reductase‐3, was
identified in prostate tissue at the mRNA level. However, the levels of 5α‐reductase‐3 …

Prostate cancer is a very common disease in industrialized countries and it is known to be
androgen-dependent. The human SRD5A2 gene encodes the prostatic (or type II) steroid 5α …

Introduction The substrate for the generation of 5α-dihydrotestosterone (DHT) is either
androstenedione (4-dione) which is first converted to androstanedione and then to DHT …

The enzyme 5α-reductase (5αR) catalyses the reduction of testosterone (T) into the more
potent androgen dihydrotestosterone (DHT). The abnormal production of DHT is associated …

Human prostatic steroid 5α-reductase, encoded by the SRD5A2 gene on chromosome band
2p23, catalyses the irreversible conversion of testosterone to dihydrotestosterone (DHT), the …

Prostate cancer often relapses during androgen‐depletion therapy, even under conditions in
which a drastic reduction of circulating androgens is observed. There is some evidence that …

BACKGROUND Whereas the embryological development of the human prostate is clearly
dependent on steroid 5α‐reductase (5α‐R) type 2 expression, the respective expression of …

BACKGROUND Currently available 5α‐reductase inhibitors are not completely effective for
treatment of benign prostate enlargement, prevention of prostate cancer (CaP), or treatment …