Cancer stem cell vaccination confers significant antitumor immunity

N Ning, Q Pan, F Zheng, S Teitz-Tennenbaum… - Cancer research, 2012 - AACR
Most studies of cancer stem cells (CSC) involve the inoculation of cells from human tumors
into immunosuppressed mice, preventing an assessment on the immunologic interactions …

Cancer stem cell vaccine inhibits metastases of primary tumors and induces humoral immune responses against cancer stem cells

L Lu, H Tao, AE Chang, Y Hu, G Shu, Q Chen… - …, 2015 - Taylor & Francis
The inability to target cancer stem cells (CSC) may be a significant factor contributing to
treatment failure. We have developed a strategy to target the CSC populations in melanoma …

Cancer stem cells: regulation programs, immunological properties and immunotherapy

D Zhang, DG Tang, K Rycaj - Seminars in cancer biology, 2018 - Elsevier
It is becoming increasingly clear that virtually all types of human cancers harbor a small
population of stem-like cancer cells (ie, cancer stem cells, CSCs). These CSCs preexist in …

Concise review: targeting cancer stem cells using immunologic approaches

Q Pan, Q Li, S Liu, N Ning, X Zhang, Y Xu… - Stem …, 2015 - academic.oup.com
Cancer stem cells (CSCs) represent a small subset of tumor cells which have the ability to
self-renew and generate the diverse cells that comprise the tumor bulk. They are …

Cancer stem cell immunology and immunotherapy: Harnessing the immune system against cancer's source

R Ruiu, L Tarone, V Rolih, G Barutello, E Bolli… - Progress in molecular …, 2019 - Elsevier
Despite recent advances in diagnosis and therapy having improved cancer outcome, many
patients still do not respond to treatments, resulting in the progression or relapse of the …

Antigen-specific T-cell response from dendritic cell vaccination using cancer stem-like cell-associated antigens

Q Xu, G Liu, X Yuan, M Xu, H Wang, J Ji, B Konda… - Stem …, 2009 - academic.oup.com
Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor, with current
treatment remaining palliative. Immunotherapies harness the body's own immune system to …

Immune responses to human cancer stem‐like cells/cancer‐initiating cells

Y Hirohashi, T Torigoe, T Tsukahara… - Cancer …, 2016 - Wiley Online Library
Cancer stem‐like cells (CSC)/cancer‐initiating cells (CIC) are defined as minor
subpopulations of cancer cells that are endowed with properties of higher tumor‐initiating …

Recent advances in cancer stem cell-targeted immunotherapy

N Badrinath, SY Yoo - Cancers, 2019 - mdpi.com
Cancer stem cells (CSCs) are one of the reasons for the relapse of cancer cells and
metastasis. They have drug resistance against most chemotherapeutic agents. CSCs are …

The role of cancer stem cells in the modulation of anti-tumor immune responses

C Maccalli, KI Rasul, M Elawad, S Ferrone - Seminars in cancer biology, 2018 - Elsevier
Tumor lesions comprise multiple subpopulations of cells including those endowed with
“stemness” properties. The latter cells are responsible of tumor initiation, metastasis …

Dendritic cell based immunotherapy using tumor stem cells mediates potent antitumor immune responses

A Dashti, M Ebrahimi, J Hadjati, A Memarnejadian… - Cancer letters, 2016 - Elsevier
Cancer stem cells (CSCs) are demonstrated to be usually less sensitive to conventional
methods of cancer therapies, resulting in tumor relapse. It is well-known that an ideal …