Sickle cell disease (SCD) is an autosomal recessive genetic condition that alters the shape
and function of the hemoglobin molecule in red blood cells. While the overall survival rate …

Purpose: To familiarize primary care providers (PCPs) with the pathophysiological
processes, diagnostic evaluation, and medical management of sickle hemoglobinopathies …

As more children are appropriately being diagnosed, the burden of sickle cell disease is
increasing greatly in Africa and in high-resource countries such as the United States and …

Sickle cell trait occurs in approximately 300 million people worldwide, with the highest
prevalence of approximately 30% to 40% in sub-Saharan Africa. Long considered a benign …

Sickle cell disease (SCD) is a collection of inherited blood disorders that affect a substantial
number of people in the US, particularly African Americans. People with SCD have an …

Sickle cell disease (SCD) is a group of inherited disorders caused by a mutation of the
hemoglobin gene, resulting in the formation of abnormal, sickle-shaped red blood cells. It is …

Sickle cell disease results in significant morbidity and mortality for those affected with this
disease. Despite the fact that every case of sickle cell disease results from the same genetic …

Sickle cell disease (SCD) is the name for a group of genetic blood disorders caused by
sickle hemoglobin (Hb S). The 2 key features of SCD are chronic hemolytic anemia and …

The sickle cell gene is pleiotropic in nature. Although it is a single gene mutation, it has
multiple phenotypic expressions that constitute the complications of sickle cell disease. The …

The survival of young children with sickle cell disease (SCD) has improved, but less is
known about older children and adolescents. We studied the Dallas Newborn Cohort (DNC) …