Advances in cDNA and monoclonal antibody technology in the 1980s fuelled the discovery
and characterization of the properties of cytokines. It became apparent that because …

▪ Abstract Analysis of cytokine mRNA and protein in rheumatoid arthritis tissue revealed that
many proinflammatory cytokines such as TNFα, IL-1, IL-6, GM-CSF, and chemokines such …

The aetiology of systemic, autoimmune, chronic inflammatory diseases—such as
rheumatoid arthritis—is not known, and their pathogenesis is complex and multifactorial …

The treatment approach to rheumatoid arthritis has undergone a major evolutionary change
in recent years in part as a consequence of growing appreciation of the severity of this …

Abstract Treatment with a chimeric mAb to TNF-α has been shown to suppress inflammation
and improve patient well-being in rheumatoid arthritis (RA), but the mechanisms of action of …

Rheumatoid arthritis (RA) is an autoimmune disease with inflammatory manifestations in the
peripheral synovial joints, which are infiltrated by activated T cells, macrophages, and …

Biological agents that inhibit the activity of proinflammatory cytokines are being investigated
for use in the treatment of rheumatoid arthritis. Thus far, two of these agents, both of which …

Although considerable progress has been made by adequate treatment with traditional
disease‐modifying antirheumatic drugs (DMARDs), therapy of rheumatoid arthritis (RA) still …

In the mid-1980s, new molecular tools enabled the biology of cytokine expression and
regulation to be studied. Our group uncovered a TNF-dependent cascade in active …

The past few years have witnessed exciting developments regarding the role of cytokines in
autoimmune diseases, particularly in rheumatoid arthritis and Crohn's disease, with the …