The identification of TAR DNA-binding protein 43 (TDP-43) as the major disease protein in
amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with ubiquitin …

Insoluble inclusions of phosphorylated TDP-43 occur in disease-affected neurons of most
patients with amyotrophic lateral sclerosis (ALS) and about half of patients with …

Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disorder of still
unknown etiology that results in loss of motoneurons, paralysis, and death, usually between …

Over the past decade, it has become clear that there is a significant overlap in the clinical
spectrum of frontotemporal lobar degeneration and amyotrophic lateral sclerosis (ALS). The …

Frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) is associated with
the accumulation of pathological neuronal and glial intracytoplasmic inclusions as well as …

TDP-43 nuclear protein is involved in several major neurodegenerative diseases that
include frontotemporal lobar degeneration with ubiquitin (FTLD-U) bodies and amyotrophic …

Therapeutic options for patients with amyotrophic lateral sclerosis (ALS) are currently
limited. However, recent studies show that almost all cases of ALS, as well as tau-negative …

The identification of the TAR DNA-binding protein 43 (TDP-43) as the ubiquitinated
cytoplasmic inclusions in frontotemporal lobar degeneration (FTLD) and amyotrophic lateral …

Hexanucleotide repeat expansions in C9orf72 are the most common genetic cause of
amyotrophic lateral sclerosis (C9 ALS). The main hypothesized pathogenic mechanisms are …

TDP-43 has been identified as a major component of ubiquitin-positive tau-negative
cytoplasmic inclusions in frontotemporal lobar degeneration with ubiquitin-positive …