The toxic effect of high concentrations of CO gas in living organisms is coherently typified at
biochemical levels by the high affinity of CO for hemoglobin and cytochromes, heme …

Carbon monoxide (CO), a gaseous second messenger, arises in biological systems during
the oxidative catabolism of heme by the heme oxygenase (HO) enzymes. HO exists as …

Stress-inducible heme oxygenase-1 (HO-1) catalyzes the oxidative cleavage of heme
yielding biliverdin, ferrous iron, and carbon monoxide (CO). Heme oxygenase activity has …

Carbon monoxide (CO) is continuously produced in mammalian cells during the
degradation of heme. It is a stable gaseous molecule that reacts selectively with transition …

Carbon monoxide (CO), a product of organic oxidation processes, arises in vivo during
cellular metabolism, most notably heme degradation. CO binds to the heme iron of most …

The ubiquitous gas, carbon monoxide (CO), is of substantial biological importance, but apart
from its affinity for reduced transition metals, particularly heme-iron, it is surprisingly …

The longstanding perception of the gas carbon monoxide (CO) as an odorless and colorless
“silent killer” began to attract the attention of the public with the arrival of the industrial age in …

Carbon monoxide (CO) has many effects in biology due to its complex biochemical activities.
These actions of CO depend primarily on its ability to bind heme proteins (Hp) and to inhibit …

Carbon monoxide (CO) is produced endogenously through the oxidative catabolism of
heme by heme oxygenase (HO). First described as a putative neuronal signaling …

Carbon monoxide (CO), a gaseous second messenger, arises in biological systems during
the oxidative catabolism of heme by the heme oxygenase (HO) enzymes. Many biological …