Chronic hypoxia aggravates monocrotaline-induced pulmonary arterial hypertension: a rodent relevant model to the human severe form of the disease

F Coste, C Guibert, J Magat, E Abell, F Vaillant… - Respiratory …, 2017 - Springer
Pulmonary arterial hypertension (PAH) is a severe form of pulmonary hypertension that
combines multiple alterations of pulmonary arteries, including, in particular, thrombotic and …

The monocrotaline model of pulmonary hypertension in perspective

JG Gomez-Arroyo, L Farkas… - … of Physiology-Lung …, 2012 - journals.physiology.org
Severe forms of pulmonary arterial hypertension (PAH) are characterized by various
degrees of remodeling of the pulmonary arterial vessels, which increases the pulmonary …

Development and characterization of an animal model of severe pulmonary arterial hypertension

Y Morimatsu, N Sakashita, Y Komohara… - Journal of vascular …, 2011 - karger.com
Pulmonary arterial hypertension (PAH) is a serious pathological phenomenon with poor
prognosis, which is associated with morphological as well as hemodynamic alteration of the …

Pulmonary artery hypertension model in rats by monocrotaline administration

C Bueno-Beti, Y Sassi, RJ Hajjar, L Hadri - Experimental Models of …, 2018 - Springer
Pulmonary arterial hypertension (PAH) is a syndrome characterized by pulmonary vascular
remodeling and vasoconstriction, leading to increased pulmonary vascular resistance, right …

Exploring the monocrotaline animal model for the study of pulmonary arterial hypertension: A network approach

R Nogueira-Ferreira, R Vitorino, R Ferreira… - Pulmonary …, 2015 - Elsevier
Pulmonary arterial hypertension (PAH) is responsible for the premature death mainly
because of progressive and severe heart failure. This disease is characterized by increased …

Rodent models of group 1 pulmonary hypertension

JJ Ryan, G Marsboom, SL Archer - Pharmacotherapy of pulmonary …, 2013 - Springer
Abstract World Health Organization category 1 pulmonary hypertension (PH) is a
heterogeneous syndrome in which PH originates in the small pulmonary arteries and is …

Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure

KR Stenmark, B Meyrick, N Galie… - … of Physiology-Lung …, 2009 - journals.physiology.org
At present, six groups of chronic pulmonary hypertension (PH) are described. Among these,
group 1 (and 1′) comprises a group of diverse diseases termed pulmonary arterial …

Advancing therapy for pulmonary arterial hypertension: can animal models help?

IM Robbins - American journal of respiratory and critical care …, 2004 - atsjournals.org
Pulmonary arterial hypertension (PAH) is a disorder predominantly affecting the small
pulmonary arteries. It can occur without an identifiable cause, primary pulmonary …

Monocrotaline‐Induced Pulmonary Hypertension in Wistar Rats

M Rey, P Hess, M Clozel - Current Protocols in Pharmacology, 2009 - Wiley Online Library
Pulmonary arterial hypertension (PAH) is a debilitating and often fatal disease characterized
by a progressive increase in pulmonary vascular resistance that leads to right ventricular …

Animal models of pulmonary arterial hypertension

R Naeije, L Dewachter - Revue des maladies respiratoires, 2007 - europepmc.org
INTRODUCTION: Pulmonary arterial hypertension (PAH) is a rare syndrome of fatigue and
dyspnoea, caused by increased pulmonary vascular resistance and right heart failure …