The study of reproductive genetics in mammals has lagged behind that of simpler and more
tractable model organisms, such as D. melanogaster, C. elegans and various yeast models …

Gene mutations, including different alleles of the same gene, are tremendously useful in
deconstructing complex developmental systems, such as reproduction, into component …

The genetic control of mammalian gametogenesis is inadequately characterized because of
a lack of mutations causing infertility. To further the discovery of genes required for …

Genetic analyses of mammalian gametogenesis and fertility have the potential to inform
about two important and interrelated clinical areas: infertility and contraception. Here, we …

Our understanding of reproduction and early embryonic development has directly enabled
our manipulation of the mouse genome for tests of gene function in vivo. In this review, we …

Infertility, defined as the inability to conceive after 1 year of unprotected intercourse, affects 1
in 10 couples in the United States (Chandra and Stephen 1998). The etiologies of infertility …

Reproduction is the sine qua non for the propagation of species and continuation of life. It is
a complex biological process that is regulated by multiple factors during the reproductive life …

(1). Because genetic defects are thought to underlie many of the unexplained pathologies in
infertility cases, animal models are expected to provide valuable clues to the underlying …

To accommodate diverse personal needs in family planning, diverse contraceptive
approaches are desirable. This goal requires identification of new contraceptive targets …

After colonization of the gonad, mouse female germ cells enter into the prophase of the first
meiotic division as a mid-gestational hallmark of gender. Perinatally, oocytes interact with …