Mesenchymal stem cells in the treatment of spinal cord injury: Mechanisms, current advances and future challenges

Y Xia, J Zhu, R Yang, H Wang, Y Li, C Fu - Frontiers in Immunology, 2023 - frontiersin.org
Spinal cord injury (SCI) has considerable impact on patient physical, mental, and financial
health. Secondary SCI is associated with inflammation, vascular destruction, and …

[HTML][HTML] Mesenchymal stem cells in the treatment of spinal cord injuries: A review

VR Dasari, KK Veeravalli, DH Dinh - World journal of stem cells, 2014 - ncbi.nlm.nih.gov
With technological advances in basic research, the intricate mechanism of secondary
delayed spinal cord injury (SCI) continues to unravel at a rapid pace. However, despite our …

Mesenchymal stem cells for spinal cord injury: current options, limitations, and future of cell therapy

F Cofano, M Boido, M Monticelli, F Zenga… - International journal of …, 2019 - mdpi.com
Spinal cord injury (SCI) constitutes an inestimable public health issue. The most crucial
phase in the pathophysiological process of SCI concerns the well-known secondary injury …

Multipotent mesenchymal stem cell-based therapies for spinal cord injury: current progress and future prospects

CW Zeng - Biology, 2023 - mdpi.com
Simple Summary Mesenchymal stem cells (MSCs) are a promising option for developing
new treatments for spinal cord injury (SCI). They can help repair damaged tissue, making …

Mesenchymal cells in the treatment of spinal cord injury: current & future perspectives

R Vawda, MG Fehlings - Current stem cell research & therapy, 2013 - ingentaconnect.com
Nearly 1.5 million people in the US live with a spinal cord injury (SCI). The cost to the
healthcare system is estimated at over $10 billion annually likely because over 65% of SCIs …

Clinical trials using mesenchymal stem cells for spinal cord injury: Challenges in generating evidence

LT de Araújo, CT Macêdo, PKF Damasceno… - Cells, 2022 - mdpi.com
Spinal cord injury (SCI) remains an important public health problem which often causes
permanent loss of muscle strength, sensation, and function below the site of the injury …

Mesenchymal stromal cell therapy in spinal cord injury: mechanisms and prospects

JL Xie, XR Wang, MM Li, ZH Tao, WW Teng… - Frontiers in Cellular …, 2022 - frontiersin.org
Spinal cord injury (SCI) often leads to severe motor, sensory, and autonomic dysfunction in
patients and imposes a huge economic cost to individuals and society. Due to its …

Human mesenchymal stem cells for spinal cord injury

M Alishahi, A Anbiyaiee, M Farzaneh… - Current Stem Cell …, 2020 - ingentaconnect.com
Spinal Cord Injury (SCI), as a devastating and life-altering neurological disorder, is one of
the most serious health issues. Currently, the management of acute SCI includes …

Regulatory role of mesenchymal stem cells on secondary inflammation in spinal cord injury

QM Pang, SY Chen, SP Fu, H Zhou… - Journal of …, 2022 - Taylor & Francis
Spinal cord injury (SCI) is a catastrophic condition with high morbidity and mortality that still
lacks effective therapeutic strategies. It is well known that the most important stage in SCI …

Mesenchymal stem cells and the neuronal microenvironment in the area of spinal cord injury

YO Mukhamedshina, OA Gracheva… - Neural regeneration …, 2019 - journals.lww.com
Cell-based technologies are used as a therapeutic strategy in spinal cord injury (SCI).
Mesenchymal stem cells (MSCs), which secrete various neurotrophic factors and cytokines …