Effect of high-fat diet on cognitive impairment in triple-transgenic mice model of Alzheimer's disease

SK Sah, C Lee, JH Jang, GH Park - Biochemical and biophysical research …, 2017 - Elsevier
Abstract High-fat diet (HFD)-induced obesity is a risk factor for cognitive impairment in
Alzheimer's disease (AD). It has been reported that two typical neuropathological markers of …

Exercise Is More Effective than Diet Control in Preventing High Fat Diet-induced β-Amyloid Deposition and Memory Deficit in Amyloid Precursor Protein Transgenic …

M Maesako, K Uemura, M Kubota, A Kuzuya… - Journal of Biological …, 2012 - ASBMB
Accumulating evidence suggests that some dietary patterns, specifically high fat diet (HFD),
increase the risk of developing sporadic Alzheimer disease (AD). Thus, interventions …

Sex-specific effects of high fat diet on indices of metabolic syndrome in 3xTg-AD mice: implications for Alzheimer's disease

AM Barron, ER Rosario, R Elteriefi, CJ Pike - PloS one, 2013 - journals.plos.org
Multiple factors of metabolic syndrome have been implicated in the pathogenesis of
Alzheimer's disease (AD), including abdominal obesity, insulin resistance, endocrine …

[HTML][HTML] Immunohistochemical analysis of tau phosphorylation and astroglial activation with enhanced leptin receptor expression in diet-induced obesity mouse …

S Koga, A Kojima, S Kuwabara, Y Yoshiyama - Neuroscience letters, 2014 - Elsevier
Accumulating evidence indicates that obesity is an independent risk factor for developing
Alzheimer disease (AD). Recent studies have shown that diet-induced obesity (DIO) …

[HTML][HTML] High-fat diet-induced memory impairment in triple-transgenic Alzheimer's disease (3xTgAD) mice is independent of changes in amyloid and tau pathology

EM Knight, IVA Martins, S Gümüsgöz, SM Allan… - Neurobiology of …, 2014 - Elsevier
Obesity and consumption of a high-fat diet are known to increase the risk of Alzheimer's
disease (AD). Diets high in fat also increase disease neuropathology and/or cognitive …

Short-term high-fat diet modulates several inflammatory, ER stress, and apoptosis markers in the hippocampus of young mice

SCBR Nakandakari, VR Munoz, GK Kuga… - Brain, Behavior, and …, 2019 - Elsevier
The consumption of saturated fatty acids is one of the leading risk factors for Alzheimer's
Disease (AD) development. Indeed, the short-term consumption of a high-fat diet (HFD) is …

Hypercholesterolemia accelerates amyloid β-induced cognitive deficits

SH Park, JH Kim, KH Choi… - International …, 2013 - spandidos-publications.com
Hypercholesterolemia is a known risk factor for Alzheimer's disease (AD). In the present
study, we investigated whether diet-induced hypercholesterolemia affects AD-like …

The effect of dietary fat consumption on Alzheimer's disease pathogenesis in mouse models

A Amelianchik, L Sweetland-Martin… - Translational Psychiatry, 2022 - nature.com
Alzheimer's disease (AD) is a fatal cognitive disorder with proteinaceous brain deposits,
neuroinflammation, cerebrovascular dysfunction, and extensive neuronal loss over time. AD …

Environmental enrichment ameliorated high-fat diet-induced Aβ deposition and memory deficit in APP transgenic mice

M Maesako, K Uemura, M Kubota, A Kuzuya… - Neurobiology of …, 2012 - Elsevier
The pathogenesis of Alzheimer's disease (AD) is tightly associated with metabolic
dysfunctions. In particular, a potential link between type 2 diabetes (T2DM) and AD has …

Metabolic stress alters antioxidant systems, suppresses the adiponectin receptor 1 and induces Alzheimer's like pathology in mice brain

JR Hahm, MH Jo, R Ullah, MW Kim, MO Kim - Cells, 2020 - mdpi.com
Oxidative stress and insulin resistance play major roles in numerous neurodegenerative
diseases, including Alzheimer's disease (AD). A high-fat diet induces obesity-associated …