Epidemiological and experimental studies have suggested that high dietary intake of fats is
associated with cognitive decline and a significantly increased risk of dementia. Since …

Background Hypothalamic dysfunction occurs early in the clinical course of Alzheimer's
disease (AD), likely contributing to disturbances in feeding behavior and metabolic function …

Alzheimer's disease (AD) is an aging-related multi-factorial disorder to which metabolic
factors contribute at what has canonically been considered a centrally mediated process …

Obesity is recognized as a significant risk factor for Alzheimer's disease (AD). Studies have
supported that obesity accelerates AD-related pathophysiology and memory impairment in …

To investigate potential dietary risk factors of Alzheimer's disease (AD), triple transgenic
(3xTg-AD) mice were exposed from 4 to 13 months of age to diets with a low n-3: n-6 …

Insulin resistance and diabetes mellitus are major risk factors for Alzheimer's disease (AD),
and studies with transgenic mouse models of AD have provided supportive evidence with …

J. Neurochem.(2010) 114, 1581–1589. Abstract Long term consumption of a high fat diet
(HFD) contributes to increased morbidity and mortality. Yet the specific effects of HFD …

Obesity is associated with impaired memory in humans, and obesity induced by high-fat
diets leads to cognitive deficits in rodents and in mouse models of Alzheimer's disease (AD) …

Alzheimer's disease (AD) is currently an incurable aging-related neurodegenerative
disorder. Recent studies give support to the hypotheses that AD should be considered as a …

Apolipoprotein E4 (ApoE4), one of three common isoforms of ApoE, is a major risk factor for
late-onset Alzheimer disease (AD). ApoE-deficient mice, as well as mice expressing human …