MYC, a downstream target of BRD-NUT, is necessary and sufficient for the blockade of differentiation in NUT midline carcinoma
AR Grayson, EM Walsh, MJ Cameron, J Godec… - Oncogene, 2014 - nature.com
NUT midline carcinoma (NMC) is an aggressive type of squamous cell carcinoma that is
defined by the presence of BRD-NUT fusion oncogenes, which encode chimeric proteins …
defined by the presence of BRD-NUT fusion oncogenes, which encode chimeric proteins …
NSD3–NUT fusion oncoprotein in NUT midline carcinoma: implications for a novel oncogenic mechanism
NUT midline carcinoma (NMC) is an aggressive subtype of squamous cell carcinoma that
typically harbors BRD4/3–NUT fusion oncoproteins that block differentiation and maintain …
typically harbors BRD4/3–NUT fusion oncoproteins that block differentiation and maintain …
Mechanistic analysis of the role of bromodomain-containing protein 4 (BRD4) in BRD4-NUT oncoprotein-induced transcriptional activation
R Wang, J You - Journal of Biological Chemistry, 2015 - ASBMB
NUT midline carcinoma (NMC) is a rare but highly aggressive cancer typically caused by the
translocation t (15; 19), which results in the formation of the BRD4-NUT fusion oncoprotein …
translocation t (15; 19), which results in the formation of the BRD4-NUT fusion oncoprotein …
Novel BRD4–NUT fusion isoforms increase the pathogenic complexity in NUT midline carcinoma
K Thompson-Wicking, RW Francis, A Stirnweiss… - Oncogene, 2013 - nature.com
Nuclear protein in testis (NUT)-midline carcinoma (NMC) is a rare, aggressive disease
typically presenting with a single t (15; 19) translocation that results in the generation of a …
typically presenting with a single t (15; 19) translocation that results in the generation of a …
Combined targeting of the BRD4–NUT–p300 axis in NUT midline carcinoma by dual selective bromodomain inhibitor, NEO2734
CD Morrison-Smith, TM Knox, I Filic, KM Soroko… - Molecular cancer …, 2020 - AACR
NUT midline carcinoma (NMC) is a rare, aggressive subtype of squamous carcinoma that is
driven by the BRD4-NUT fusion oncoprotein. BRD4, a BET protein, binds to chromatin …
driven by the BRD4-NUT fusion oncoprotein. BRD4, a BET protein, binds to chromatin …
The oncogenic BRD4-NUT chromatin regulator drives aberrant transcription within large topological domains
AA Alekseyenko, EM Walsh, X Wang… - Genes & …, 2015 - genesdev.cshlp.org
NUT midline carcinoma (NMC), a subtype of squamous cell cancer, is one of the most
aggressive human solid malignancies known. NMC is driven by the creation of a …
aggressive human solid malignancies known. NMC is driven by the creation of a …
Differentiation of NUT midline carcinoma by epigenomic reprogramming
BE Schwartz, MD Hofer, ME Lemieux, DE Bauer… - Cancer research, 2011 - AACR
NUT midline carcinoma (NMC) is a lethal pediatric tumor defined by the presence of BRD-
NUT fusion proteins that arrest differentiation. Here we explore the mechanisms underlying …
NUT fusion proteins that arrest differentiation. Here we explore the mechanisms underlying …
Perturbation of BRD4 protein function by BRD4-NUT protein abrogates cellular differentiation in NUT midline carcinoma
NUT midline carcinoma (NMC) belongs to a class of highly lethal and poorly differentiated
epithelial cancers arising mainly in human midline organs. NMC is caused by the …
epithelial cancers arising mainly in human midline organs. NMC is caused by the …
Supercharging BRD4 with NUT in carcinoma
KP Eagen, CA French - Oncogene, 2021 - nature.com
NUT carcinoma (NC) is an extremely aggressive squamous cancer with no effective therapy.
NC is driven, most commonly, by the BRD4-NUT fusion oncoprotein. BRD4-NUT combines …
NC is driven, most commonly, by the BRD4-NUT fusion oncoprotein. BRD4-NUT combines …
Pathogenesis of NUT midline carcinoma
CA French - Annual Review of Pathology: Mechanisms of …, 2012 - annualreviews.org
NUT midline carcinoma (NMC), an aggressive form of squamous cell carcinoma, is defined
by the presence of acquired chromosomal rearrangements involving NUT, usually BRD4 …
by the presence of acquired chromosomal rearrangements involving NUT, usually BRD4 …