Neuropathic pain often fails to respond to conventional pain management procedures. here
we review the aetiology of neuropathic pain as would result from peripheral neuropathy or …

Inflammation is the process by which an organism responds to tissue injury involving both
immune cell recruitment and mediator release. Diverse causes of neuropathic pain are …

Peripheral nerve injury of various types, for example complete nerve transection or loose
nerve constrictions (Bennett model), results in changes in expression of a large number of …

Nociceptive pain alerts the body to potential or actual tissue damage. By contrast,
neuropathic or" noninflammatory" pain, which results from injury to the nervous system …

The past decade has seen great progress in understanding its causes and in finding new
drugs that promise great benefit. An early outcome of the research has been the observation …

Neuropathic pain can result from injury to, or disease of the nervous system. It is notoriously
difficult to treat. Peripheral nerve injury promotes Schwann cell activation and invasion of …

Neuropathic pain represents a major problem in clinical medicine because it causes
debilitating suffering and is largely resistant to currently available analgesics. A …

The hypothesis that prostaglandins contribute to hyperalgesia resulting from nerve injury
was tested in rats in which the sciatic nerve was partially transected on one side …

Injury to sensory axons often has the paradoxical effect of inducing positive sensory
disturbances; paraesthesias and chronic neuropathic pain. Such symptoms can be at least …

Damage to peripheral nerves often results in pain and hyperalgesia. We suggest that nerve
damage causes an inflammatory response in which cells associated with the nerve release …