SIR—Most of Guiloff and colleague's criticisms relate to the absence of the results of
secondary exploratory analyses. Intention-to-treat analysis (ITT) deals with the difficulty …

Objectives To determine the safety and efficacy of lithium for the treatment of amyotrophic
lateral sclerosis (ALS) in a randomised, placebo controlled, double blind, sequential trial …

HONOLULU—Patients enrolled in clinical trials for therapies for amyotrophic lateral
sclerosis (ALS) are different from those in the general ALS population, according to a new …

Amyotrophic lateral sclerosis (ALS; motor neuron disease) is a relentlessly progressive
disorder. After half a century of trials, only one drug with modest disease-modifying potency …

Is the lithium-for-ALS genie back in the bottle? | Neurology Skip to main content Skip to main
content AAN.com AAN Publications Author Center About the Journals Press Releases Go to …

Richard Bedlack hates the term “compassionate use”. It implies that people who are not in
favour of this often controversial practice are not compassionate, says the Duke University …

Recent studies of amyotrophic lateral sclerosis (ALS) have led to an expectation that
therapies will be found to stop progression of this disease, if not restore lost motor function …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterised by
progressive motor neuron destruction. There is no effective cure and patients affected …

BackgroundAmyotrophic lateral sclerosis (ALS) is a progressive disease with no effective
treatment. In an initial study, riluzole decreased mortality and slowed muscle-strength …

In the article by Bensimon et al. in this issue [1], the authors address the important question
whether the neuroprotectant riluzole exerts measurable beneficial effects also in ALS …