Ultrastable, redispersible, small, and highly organomodified mesoporous silica nanotherapeutics

YS Lin, N Abadeer, KR Hurley… - Journal of the American …, 2011 - ACS Publications
Practical biomedical application of mesoporous silica nanoparticles is limited by poor
particle dispersity and stability due to serious irreversible aggregation in biological media …

Critical considerations in the biomedical use of mesoporous silica nanoparticles

YS Lin, KR Hurley, CL Haynes - The journal of physical chemistry …, 2012 - ACS Publications
Since the first report of mesoporous silica nanoparticles in 2001, many efforts have been
made to develop them for biomedical applications. With the emergence of new designs and …

Functionalized mesoporous silica nanoparticles and biomedical applications

TTH Thi, TNQ Nguyen, DT Hoang, DH Nguyen - Materials Science and …, 2019 - Elsevier
Since the first report in early 1990s, mesoporous silica nanoparticles (MSNs) have
progressively attracted the attention of scientists due to their potential applications in physic …

Stability of small mesoporous silica nanoparticles in biological media

YS Lin, N Abadeer, CL Haynes - Chemical Communications, 2011 - pubs.rsc.org
In this work, sub-50 nm pegylated mesoporous silica nanoparticles prepared with
hydrothermal treatment are shown to have long-term stability in various media at both room …

Mesoporous silica microparticles enhance the cytotoxicity of anticancer platinum drugs

Z Tao, B Toms, J Goodisman, T Asefa - Acs Nano, 2010 - ACS Publications
We report on the endocytosis and the time-dependent enhanced cytotoxicity of anticancer
platinum drugs when the drugs are combined with (or loaded into) one of the two most …

Application of mesoporous silica nanoparticles as drug delivery carriers for chemotherapeutic agents

Y Alyassin, EG Sayed, P Mehta, K Ruparelia… - Drug Discovery …, 2020 - Elsevier
Highlights•Structural and geometrical features of mesoporous silica can benefit drug
delivery.•Coupled with therapeutic agents, targeting for a host of cancers is …

Mesostructured silica for optical functionality, nanomachines, and drug delivery

Y Klichko, M Liong, E Choi, S Angelos… - Journal of the …, 2009 - Wiley Online Library
Silica thin films and nanoparticles prepared using sol–gel chemistry are derivatized with
active molecules to generate new functional materials. The mild conditions associated with …

Biocompatibility, biodistribution, and drug‐delivery efficiency of mesoporous silica nanoparticles for cancer therapy in animals

J Lu, M Liong, Z Li, JI Zink, F Tamanoi - Small, 2010 - Wiley Online Library
Mesoporous silica nanoparticles (MSNs) are a promising material for drug delivery. In this
Full Paper, MSNs are first shown to be well tolerated, as demonstrated by serological …

Mesoporous silica nanomaterial-based biotechnological and biomedical delivery systems

S Giri, BG Trewyn, VSY Lin - 2007 - Taylor & Francis
This review details the recent advancements in the design of mesoporous silica
nanomaterials for controlled release drug, gene and neurotransmitter delivery applications …

Multifunctional mesoporous silica-based nanocomposites: Synthesis and biomedical applications

S Noreen, A Maqbool, I Maqbool, A Shafique… - Materials Chemistry and …, 2022 - Elsevier
Nanotechnology is an emerging area of research for the exploitation of various scientific
advancements for controlling material configuration at a reduced dimensional scale. With …