AU-rich elements and associated factors: are there unifying principles?

C Barreau, L Paillard, HB Osborne - Nucleic acids research, 2005 - academic.oup.com
The control of mRNA stability is an important process that allows cells to not only limit, but
also rapidly adjust, the expression of regulatory factors whose over expression may be …

AREsite2: an enhanced database for the comprehensive investigation of AU/GU/U-rich elements

J Fallmann, V Sedlyarov, A Tanzer… - Nucleic acids …, 2016 - academic.oup.com
AREsite2 represents an update for AREsite, an on-line resource for the investigation of AU-
rich elements (ARE) in human and mouse mRNA 3′ UTR sequences. The new updated …

A broader role for AU-rich element-mediated mRNA turnover revealed by a new transcriptional pulse strategy

N Xu, P Loflin, CYA Chen, AB Shyu - Nucleic acids research, 1998 - academic.oup.com
The widespread occurrence of AU-rich elements (AREs) in mRNAs encoding proteins with
diversified functions and synthesized under a vast variety of physiological conditions …

Rapid degradation of AU-rich element (ARE) mRNAs is activated by ribosome transit and blocked by secondary structure at any position 5′ to the ARE

AM Curatola, MS Nadal… - Molecular and cellular …, 1995 - Taylor & Francis
The 3′ noncoding region (NCR) AU-rich element (ARE) selectively confers rapid
degradation on many mRNAs via a process requiring translation of the message. The role of …

Modulation of the fate of cytoplasmic mRNA by AU-rich elements: key sequence features controlling mRNA deadenylation and decay

N Xu, CYA Chen, AB Shyu - Molecular and cellular biology, 1997 - Am Soc Microbiol
Regulation of cytoplasmic deadenylation has a direct impact on the fate of mRNA and,
consequently, its expression in the cytoplasm. AU-rich elements (AREs) found in the 3 …

mRNA Decay Mediated by Two Distinct AU-Rich Elements from c-fos and Granulocyte-Macrophage Colony-Stimulating Factor Transcripts: Different Deadenylation …

CYA Chen, N Xu, AB Shyu - Molecular and cellular biology, 1995 - Taylor & Francis
Poly (A) tail removal is a critical first step in the decay pathway for many yeast and
mammalian mRNAs. Poly (A) shortening rates can be regulated by cis-acting sequences …

AU-rich elements: characterization and importance in mRNA degradation

CYA Chen, AB Shyu - Trends in biochemical sciences, 1995 - cell.com
Adenylate/uridylate-rich elements (AREs) are found in the 3′ untranslated region (UTR) of
many messenger RNAs (mRNAs) that code for proto-oncogenes, nuclear transcription …

AREsite: a database for the comprehensive investigation of AU-rich elements

AR Gruber, J Fallmann, F Kratochvill… - Nucleic acids …, 2010 - academic.oup.com
AREsite is an online resource for the detailed investigation of AU-rich elements (ARE) in
vertebrate mRNA 3′-untranslated regions (UTRs). AREs are one of the most prominent cis …

Distinct domains of AU-rich elements exert different functions in mRNA destabilization and stabilization by p38 mitogen-activated protein kinase or HuR

R Winzen, G Gowrishankar, F Bollig… - … and cellular biology, 2004 - Taylor & Francis
AU-rich elements (AREs) control the expression of numerous genes by accelerating the
decay of their mRNAs. Rapid decay and deadenylation of β-globin mRNA containing AU …

[HTML][HTML] Emerging evidence of translational control by AU-rich element-binding proteins

H Otsuka, A Fukao, Y Funakami, KE Duncan… - Frontiers in …, 2019 - frontiersin.org
RNA-binding proteins (RBPs) are key regulators of posttranscriptional gene expression and
control many important biological processes including cell proliferation, development, and …