Hoxa-5 is a homeobox gene that is highly expressed in the developing mouse lung.
However, little is known about the molecular mechanisms controlling expression. We …

Hox genes are sequence-specific DNA transcription factors, which are important in
embryonic development and are expressed in a number of fetal tissues, including the lung …

We have previously described a 5cis‐acting retinoic acid response element that is required
for a subset of Hoxa4 expression, including the midgestation mouse lung. As both retinoids …

BACKGROUND: Hox transcription factors modulate signaling pathways controlling organ
morphogenesis and maintain cell fate and differentiation in adults. Retinoid signaling, key in …

It has finally happened. Once the domain of molecular embryologists, Hox genes are now
the subject of investigation in the study of the biology of specific cell and tissue types such as …

Materials and Methods Cell Culture HBF were obtained from bronchial explants, which were
cultured in 1: 1 RPMI 1640/Fl2 supplemented with 17ng/ml epidermal growth factor, 51Lg/ml …

Hoxa5 is essential for development of several organs and tissues. In the respiratory system,
loss of Hoxa5 function causes neonatal death due to respiratory distress. Expression of …

Hox genes encode transcription factors governing complex developmental processes in
several organs. A subset of Hox genes are expressed in the developing lung. Except for …

Exogenous retinoids alter pattern formation and differentiation in many developing systems,
such as limb, vertebrae, and central nervous system. Many of these effects are mediated by …

Homeobox (Hox)-containing factors have been shown to play regulatory roles on lung
development. Although HoxB3 gene expression is detected in the prenatal lung during …