A computational framework to explore large-scale biosynthetic diversity
JC Navarro-Muñoz, N Selem-Mojica… - Nature chemical …, 2020 - nature.com
Genome mining has become a key technology to exploit natural product diversity. Although
initially performed on a single-genome basis, the process is now being scaled up to mine …
initially performed on a single-genome basis, the process is now being scaled up to mine …
CAGECAT: The CompArative GEne Cluster Analysis Toolbox for rapid search and visualisation of homologous gene clusters
Background Co-localized sets of genes that encode specialized functions are common
across microbial genomes and occur in genomes of larger eukaryotes as well. Important …
across microbial genomes and occur in genomes of larger eukaryotes as well. Important …
Integrated metabolomic–genomic workflows accelerate microbial natural product discovery
The pairing of analytical chemistry with genomic techniques represents a new wave in
natural product chemistry. With an increase in the availability of sequencing and assembly of …
natural product chemistry. With an increase in the availability of sequencing and assembly of …
MIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters
With an ever-increasing amount of (meta) genomic data being deposited in sequence
databases,(meta) genome mining for natural product biosynthetic pathways occupies a …
databases,(meta) genome mining for natural product biosynthetic pathways occupies a …
EvoMining reveals the origin and fate of natural product biosynthetic enzymes
N Sélem-Mojica, C Aguilar… - Microbial …, 2019 - microbiologyresearch.org
Natural products (NPs), or specialized metabolites, are important for medicine and
agriculture alike, and for the fitness of the organisms that produce them. NP genome-mining …
agriculture alike, and for the fitness of the organisms that produce them. NP genome-mining …
BiG-SLiCE: A highly scalable tool maps the diversity of 1.2 million biosynthetic gene clusters
Background Genome mining for biosynthetic gene clusters (BGCs) has become an integral
part of natural product discovery. The> 200,000 microbial genomes now publicly available …
part of natural product discovery. The> 200,000 microbial genomes now publicly available …
Genome mining methods to discover bioactive natural products
Covering: 2016 to 2021 With genetic information available for hundreds of thousands of
organisms in publicly accessible databases, scientists have an unprecedented opportunity …
organisms in publicly accessible databases, scientists have an unprecedented opportunity …
A roadmap for natural product discovery based on large-scale genomics and metabolomics
Actinobacteria encode a wealth of natural product biosynthetic gene clusters, whose
systematic study is complicated by numerous repetitive motifs. By combining several metrics …
systematic study is complicated by numerous repetitive motifs. By combining several metrics …
eSNaPD: a versatile, web-based bioinformatics platform for surveying and mining natural product biosynthetic diversity from metagenomes
BVB Reddy, A Milshteyn, Z Charlop-Powers… - Chemistry & biology, 2014 - cell.com
Summary Environmental Surveyor of Natural Product Diversity (eSNaPD) is a web-based
bioinformatics and data aggregation platform that aids in the discovery of gene clusters …
bioinformatics and data aggregation platform that aids in the discovery of gene clusters …
Computational approaches to natural product discovery
MH Medema, MA Fischbach - Nature chemical biology, 2015 - nature.com
Starting with the earliest Streptomyces genome sequences, the promise of natural product
genome mining has been captivating: genomics and bioinformatics would transform …
genome mining has been captivating: genomics and bioinformatics would transform …