Microbial genome mining is a rapidly developing approach to discover new and novel
secondary metabolites for drug discovery. Many advances have been made in the past …

All organisms produce specialized organic molecules, ranging from small volatile chemicals
to large gene-encoded peptides, that have evolved to provide them with diverse cellular and …

Covering: up to 2019 Phylogenetic methods become increasingly important in natural
product research. The growing amount of genetic data available today is enabling us to infer …

Natural products originating from microorganisms are frequently used in antimicrobial and
anticancer drugs, pesticides, herbicides or fungicides. In the last years, the increasing …

Genome sequencing has created unprecedented opportunities for natural-product discovery
and new insight into the diversity and distributions of natural-product biosynthetic gene …

Covering: 2005 up to 2019 Natural products are of paramount importance in human
medicine. Not only are most antibacterial and anticancer drugs derived directly from or …

Complex microbial ecosystems contain large reservoirs of unexplored biosynthetic diversity.
Here we provide an experimental framework and data analysis tool to facilitate the targeted …

Bacterial specialized metabolites are a proven source of antibiotics and cancer therapies,
but whether we have sampled all the secondary metabolite chemical diversity of cultivated …

Microbial natural products are an invaluable source of evolved bioactive small molecules
and pharmaceutical agents. Next-generation and metagenomic sequencing indicates …

Microbial genome mining for drug discovery and development has been accelerating in
recent years, driven by technical advancements in genome sequencing, bioinformatics …