Background Antibiotic resistance in bacteria spreads quickly, overtaking the pace at which
new compounds are discovered and this emphasizes the immediate need to discover new …

Genome sequencing has revealed that bacteria contain many more biosynthetic gene
clusters than predicted based on the number of secondary metabolites discovered to date …

Genome sequencing is rapidly changing the field of natural products research by providing
opportunities to assess the biosynthetic potential of strains prior to chemical analysis or …

Bottromycin A2 is a structurally unique ribosomally synthesized and post‐translationally
modified peptide (RiPP) that possesses potent antibacterial activity towards multidrug …

For more than half a century the pharmaceutical industry has sifted through natural products
produced by microbes, uncovering new scaffolds and fashioning them into a broad range of …

Intergeneric microbial interactions may originate a significant fraction of secondary
metabolic gene regulation in nature. Herein, we expose a genomically characterized …

Microbial natural products, particularly those produced by filamentous Actinobacteria,
underpin the majority of clinically used antibiotics. Unfortunately, only a few new antibiotic …

Identifying functional enzymes for the catalysis of specific biochemical reactions is a major
bottleneck in the de novo design of biosynthesis and biodegradation pathways …

Soils host diverse microbial communities that include filamentous actinobacteria
(actinomycetes). These bacteria have been a rich source of useful metabolites, including …

Filamentous marine cyanobacteria are extraordinarily rich sources of structurally novel,
biomedically relevant natural products. To understand their biosynthetic origins as well as …