Covering: up to mid-2009 The phylum Actinobacteria hosts diverse high G+ C, Gram-
positive bacteria that have evolved a complex chemical language of natural product …

Nature's ability to generate diverse natural products from simple building blocks has inspired
combinatorial biosynthesis. The knowledge-based approach to combinatorial biosynthesis …

Actinomycetes are known for producing diverse secondary metabolites. Combining
genomics with untargeted data-dependent tandem MS and molecular networking, we …

Natural products from microbes have provided humans with beneficial antibiotics for
millennia. However, a decline in the pace of antibiotic discovery exerts pressure on human …

Microbial and plant specialized metabolites constitute an immense chemical diversity, and
play key roles in mediating ecological interactions between organisms. Also referred to as …

Advances in genomics and metabolomics have made clear in recent years that microbial
biosynthetic capacities on Earth far exceed previous expectations. This is attributable, in …

Nonribosomally synthesized peptides (NRPs) are natural products with widespread
applications in medicine and biotechnology. Many algorithms have been developed to …

Some bacterial clades are important sources of novel bioactive natural products. Estimating
the magnitude of chemical diversity available from such a resource is complicated by issues …

The actinomycetes are well-known bioactive natural product producers, comprising the
Streptomycetes, the richest drug-prolific family in all kingdoms, producing therapeutic …

The identity and biological activity of most metabolites still remain unknown. A bottleneck in
the exploration of metabolite structures and pharmaceutical activities is the compound …