An estimated 5.7 million Americans suffer from Alzheimer's disease in the United States, with
no disease-modifying treatments to prevent or treat cognitive deficits associated with the …

The complement system is a critical element of the innate immune system recognizing and
killing, or targeting for destruction, otherwise pathogenic organisms. In addition to triggering …

The spectrum of inflammatory diseases is nowadays considered to include diverse diseases
of the central nervous system (CNS). Current evidence suggests that syndromes such as …

Increasing evidence suggests that inflammatory and immune components in brain are
important in Alzheimer's disease (AD) and anti-inflammatory and immunotherapeutic …

This review discusses key findings indicating potential roles of the complement (C)-system
in chronic inflammation in Alzheimer's disease (AD) brain. Although there is no means to …

The brain is considered to be an immune privileged site, because the blood–brain barrier
limits entry of blood borne cells and proteins into the central nervous system (CNS). As a …

There is increasing evidence from genetic, immunohistochemical, proteomic and
epidemiological studies as well as in model systems that complement activation has an …

C1q, the recognition component of the classical complement activation pathway, is a
multifunctional protein of the immune system that has been shown to be expressed in the …

The complement inflammatory cascade is an essential component of the phylogenetically
ancient innate immune response and is crucial to our natural ability to ward off infection …

Increasing evidence supports a role of neuroinflammation in the pathogenesis of
Alzheimer's disease (AD). Previously, we identified a neuron–glia signaling pathway …