Heme oxygenase (HO)-1 is an inducible enzyme that catalyzes the first and rate-limiting step
in the oxidative degradation of free heme into ferrous iron, carbon monoxide (CO), and …

Upon injury, prolonged inflammation and oxidative stress may cause pathological wound
healing and fibrosis, leading to formation of excessive scar tissue. Fibrogenesis can occur in …

Abstract Heme oxygenase-1 (HO-1) protects endothelial cells (EC) from undergoing
apoptosis. This effect is mimicked by CO, generated via the catabolism of heme by HO-1 …

Heme is a versatile molecule in nature and serves as the prosthetic moiety for numerous
hemoproteins involved in oxygen delivery, electron transfer, and signal transduction. 1 …

抄録 Heme oxygenase (HO) catalyzes the rate-limiting step in heme degradation to produce
carbon monoxide (CO), iron, and biliverdin. Biliverdin is subsequently converted to bilirubin …

Heme oxygenase (HO) is responsible for the physiological breakdown of heme into
equimolar amounts of biliverdin, carbon monoxide, and iron. Three isoforms (HO‐1, HO‐2 …

ABSTRACT Heme oxygenase‐1 (HO‐1), which degrades heme into three products (carbon
monoxide, free iron, and biliverdin), plays a protective role in many models of disease via its …

The heme oxygenase (HO) system is essential for heme and iron homeostasis and
necessary for adaptation to cell stress. HO degrades heme to biliverdin (BV), carbon …

The heme oxygenase-1 (HO-1) enzyme system remains an attractive therapeutic target for
the treatment of inflammatory conditions. HO-1, a cellular stress protein, serves a vital …

Tissue injury may result as a consequence of a physical, chemical, or biological insult. Such
injury recruits an adaptive response to restore homeostasis and protect against further …