We developed a method to highly purify germline stem cells (GSCs) from the Drosophila
ovary, one of the best understood types of adult stem cell. GSCs express variant isoforms of …

Stem cells possess the capacity to generate two cells of distinct fate upon division: one cell
retaining stem cell identity and the other cell destined to differentiate. These cell fates are …

Germline stem cells (GSCs), which can self-renew and generate differentiated progeny, are
unique stem cells in that they are solely dedicated to reproduction and transmit genetic …

The Drosophila germline lineage depends on a complex microenvironment of extrinsic and
intrinsic factors that regulate the self-renewing and asymmetric divisions of dedicated stem …

Germline stem cells (GSCs) in Drosophila are a valuable model to explore of how adult stem
cells are regulated in vivo. Genetic dissection of this system has shown that stem cell fate is …

Highly potent animal stem cells either self renew or launch complex differentiation programs,
using mechanisms that are only partly understood. Drosophila female germline stem cells …

Adult stem cells are believed to be maintained by a specialized microenvironment, the
niche, which provides short-range signals that either instruct stem cells to self-renew or …

Much effort is being invested in defining the intrinsic and extrinsic factors that control stem
cell maintenance and proliferation. Recent studies have identified a signaling hierarchy …

A fundamental yet unexplored question in stem cell biology is how the fate of tissue stem
cells is initially determined during development. In Drosophila, germline stem cells (GSCs) …

The homeostasis of self-renewal and differentiation in stem cells is controlled by intrinsic
signals and their niche. We conducted a large-scale RNA interference (RNAi) screen in …