Simple Summary Tumor growth in solid cancers requires adequate nutrient and oxygen
supply, provided by blood vessels created by angiogenesis. Numerous studies have …

IL-1 belongs to a family of 11 members and is one of the seven receptor-agonists with pro-
inflammatory activity. Beyond its biological role as a regulator of the innate immune …

Interleukin-1 (IL-1) represents a family of two agonistic proteins, IL-1α and IL-1β, that are
pleiotropic and affect hemopoiesis, inflammation, and immunity. In the context of the …

The relationship between inflammation and cancer has attracted attention for a long time.
The inflammatory tumor microenvironment consists of inflammatory cells, chemokines …

The isolation, purification, and molecular cloning of an increasing number of cytokines and
their receptors have allowed major advances in our understanding of the relevance of these …

Tumor and host cells frequently express interleukin-8 (IL-8). IL-8 has been shown to be
motogenic, mitogenic, and angiogenic and to play important roles in human tumor …

In the last decade, several groups have shown a direct correlation between the
inappropriate or ectopic release of interleukin (IL)-8 by tumor cells in vitro and their growth …

Many pathological processes including wound healing, chronic inflammation and cancer
require angiogenesis, ie, the formation of new vasculature in the lesions. Accumulating …

The role of microenvironment interleukin 1 (IL-1) on 3-methylcholanthrene (3-MCA)–induced
carcinogenesis was assessed in IL-1–deficient mice, ie, IL-1β−/−, IL-1α−/−, IL …

Chronic inflammatory mediators exert pleiotropic effects in the development of cancer. On
the one hand, inflammation favors carcinogenesis, malignant transformation, tumor growth …