Cytokines play a crucial role in tumor initiation and progression. Here, we demonstrate that
interleukin (IL)‐6 is a key factor by driving tumor progression from benign to malignant …

Malignant cells thrive in a highly specialized, stromal environment, which harbors support
cells, blood vessels, and diverse leukocyte populations. There is increasing evidence that …

Simple Summary Cytokines are important molecular players in cancer development,
progression, and potential targets for treatment. Despite being small and overlooked …

During the neoplastic progression, macrophages as well as dendritic and NK cells are
attracted into the tumor site and initiate the immune response against transformed cells …

It is widely accepted that the tumor microenvironment (TUMIC) plays a major role in cancer
and is indispensable for tumor progression. The TUMIC involves many “players” going well …

Since Virchow first proposed in 1863 that tumors could originate from sites of chronic
inflammation, it has been well established that chronic inflammation both contributes to …

This article reviews the evidence for macrophages playing an important role in the
regulation of tumor angiogenesis. Findings in mouse models show that macrophages …

This review article has described briefly studies supporting the concept that IL-8 expression
and its regulation by inflammatory cytokines like IL-l may play an important role in controlling …

Leukocytes are cells of defense. Their main function is to protect our body against invading
microorganisms. Some leukocytes, in particular, polymorphonuclear and monocytes …

Cutaneous melanoma accounts for only about 7% of skin cancers but is causing almost 90%
of deaths. Melanoma cells have a distinct repertoire of mutations from other cancers, a high …