ROM2 is associated with Cryptococcus neoformans virulence. We examined additional roles
of ROM2 in C. neoformans and found that ROM2 plays a role in several cell functions …

The pathogenic yeast Cryptococcus neoformans causes nearly 200,000 deaths annually in
immunocompromised individuals. Cryptococcus cells can undergo substantial …

Cell wall biogenesis and integrity are crucial for fungal growth, pathogenesis and survival,
and are attractive targets for antifungal therapy. In this study, we identify, delete and analyse …

Cryptococcus neoformans is a fungus that causes the majority of fatal cryptococcal
meningitis cases worldwide. This pathogen is capable of assuming different morphotypes …

The precise regulation of morphogenesis is a key mechanism by which cells respond to a
variety of stresses, including those encountered by microbial pathogens in the host. The …

Cryptococcus neoformans is a prevalent human fungal pathogen that must survive within
various tissues in order to establish a human infection. We have identified the C …

The Cryptococcus neoformans NRG1 gene was identified using gene microarrays to define
putative transcription factor genes regulated by the cyclic AMP (cAMP) signal transduction …

The Rim101 protein is a conserved pH-responsive transcription factor that mediates
important interactions between several fungal pathogens and the infected host. In the …

Human studies have shown associations between cryptococcal meningitis and reduced IgM
memory B cell levels, and studies in IgM-and/or B cell-deficient mice have demonstrated …

Infectious microorganisms often play a role in modulating the immune responses of their
infected hosts. We demonstrate that Cryptococcus neoformans signals through the Rim101 …