Cryptococcosis is caused by the opportunistic pathogen Cryptococcus neoformans or by the
primary pathogen Cryptococcus gattii. Epidemiological studies suggest that patients infected …

Microbes exist in complex communities in the environment. The interaction between fungi,
such as the opportunistic pathogen Cryptococcus neoformans, and antagonistic …

The pathogenic species of Cryptococcus are a major cause of mortality owing to severe
infections in immunocompromised as well as immunocompetent individuals. Although …

Acidification of vesicular compartments plays an important role in a number of cellular
transport processes, including protein secretion, metal cofactor insertion, glycosylation and …

The study of quantitative traits provides a window on the interactions between multiple
unlinked genetic loci. The interaction between hosts and pathogenic microbes, such as …

The basidiomycete fungus Cryptococcus neoformans infects humans via inhalation of
desiccated yeast cells or spores from the environment. In the absence of effective immune …

Nutrient sensing is critical for adaptation of fungi to environmental and host conditions. The
conserved cAMP/PKA signaling pathway contributes to adaptation by sensing the …

In eukaryotic cells, the unfolded protein response (UPR) pathway plays a crucial role in
cellular homeostasis of the endoplasmic reticulum (ER) during exposure to diverse …

Cryptococcus neoformans is a ubiquitous human fungal pathogen. This pathogen can
undergo morphotype transition between the yeast and the filamentous form and such …

The ability of Cryptococcus neoformans to cause disease in humans varies significantly
among strains with highly related genotypes. In general, environmental isolates of …