[HTML][HTML] The Link between Morphotype Transition and Virulence in Cryptococcus neoformans

L Wang, B Zhai, X Lin - PLoS pathogens, 2012 - journals.plos.org
Cryptococcus neoformans is a ubiquitous human fungal pathogen. This pathogen can
undergo morphotype transition between the yeast and the filamentous form and such …

Caught red feathered: infection from cockatoo to human and mice reveals genetic plasticity of Cryptococcus neoformans during mammalian passage

DG Cohen, RA Wingert - Tissue Barriers, 2024 - Taylor & Francis
The fungus Cryptococcus neoformans is pervasive in our environment and causes the
infectious disease cryptococcosis in humans, most commonly in immunocompromised …

Genetic and Genomic Analyses Reveal Boundaries between Species Closely Related to Cryptococcus Pathogens

AR Passer, MA Coelho, RB Billmyre, M Nowrousian… - Mbio, 2019 - Am Soc Microbiol
Speciation is a central mechanism of biological diversification. While speciation is well
studied in plants and animals, in comparison, relatively little is known about speciation in …

[HTML][HTML] Cell-to-cell spread and massive vacuole formation after Cryptococcus neoformans infection of murine macrophages

M Alvarez, A Casadevall - BMC immunology, 2007 - Springer
Background The interaction between macrophages and Cryptococcus neoformans (Cn) is
critical for containing dissemination of this pathogenic yeast. However, Cn can either lyse …

[HTML][HTML] Importance of Clinical Isolates in Cryptococcus neoformans Research

KM Jackson, M Ding, K Nielsen - Journal of Fungi, 2023 - mdpi.com
The human pathogenic fungus Cryptococcus neoformans is a global health concern.
Previous research in the field has focused on studies using reference strains to identify …

Dissecting the Roles of the Calcineurin Pathway in Unisexual Reproduction, Stress Responses, and Virulence in Cryptococcus deneoformans

C Fu, N Donadio, ME Cardenas, J Heitman - Genetics, 2018 - academic.oup.com
Abstract The Ca2+/calmodulin-dependent protein phosphatase calcineurin orchestrates
sexual reproduction, stress responses, and virulence via branched downstream pathways in …

Cryptococcus neoformans releases proteins during intracellular residence that affect the outcome of the fungal–macrophage interaction

EH Jung, YD Park, Q Dragotakes, LS Ramirez… - …, 2022 - academic.oup.com
Cryptococcus neoformans is a facultative intracellular pathogen that can replicate and
disseminate in mammalian macrophages. In this study, we analyzed fungal proteins …

[HTML][HTML] Titan cell production in Cryptococcus neoformans reshapes the cell wall and capsule composition during infection

L Mukaremera, KK Lee, J Wagener, DL Wiesner… - The Cell Surface, 2018 - Elsevier
Cryptococcus neoformans is a human fungal pathogen that often causes infections in
immunocompromised individuals. Upon inhalation into the lungs C. neoformans …

Phospholipid-Binding Protein Cts1 Controls Septation and Functions Coordinately with Calcineurin in Cryptococcus neoformans

DS Fox, GM Cox, J Heitman - Eukaryotic cell, 2003 - Am Soc Microbiol
Cryptococcus neoformans is an opportunistic fungal pathogen that causes life-threatening
meningoencephalitis in immunocompromised patients. The Ca2+-calmodulin-activated …

Landscape of gene expression variation of natural isolates of Cryptococcus neoformans in response to biologically relevant stresses

CH Yu, Y Chen, CA Desjardins, JL Tenor… - Microbial …, 2020 - microbiologyresearch.org
Cryptococcus neoformans is an opportunistic fungal pathogen that at its peak epidemic
levels caused an estimated million cases of cryptococcal meningitis per year worldwide …