Importance of the field: Piperacillin-tazobactam is a frequently prescribed intravenous
antibiotic for moderate to severe infections used in hospital settings because of its broad …

Ten volunteers received piperacillin (4 g), piperacillin (4 g) plus tazobactam (0.5 g)(Tazocin),
and ticarcillin (3 g) plus clavulanic acid (0.2 g)(Timentin) intravenously over 30 min in a …

Ceftolozane/tazobactam is approved for treatment of complicated intra-abdominal infection
(cIAI) and complicated urinary tract infection (cUTI) with renal function-based dose …

The pharmacokinetic properties of piperacillin/tazobactam are summarized. The data on
piperacillin show that the behaviour of this well established agent is the same when given in …

Tazobactam is an irreversible inhibitor of many β‐lactamases. In combination with
piperacillin, tazobactam exhibits synergy against many β‐lactamase? producing bacteria …

The pharmacokinetics of tazobactam (500 mg) administered intravenously alone were
compared with the pharmacokinetics of tazobactam coadministered with piperacillin (4 g) …

With the introduction of piperacillin/tazobactam to the North American market, hospitals have
been faced with the task of making a decision regarding its formulary role. In view of its …

With increasing use of once-daily aminoglycoside dosing and renewed interest in
continuous infusions of p-lactam agents, there is a need to study the interaction between …

While extended infusions of piperacillin-tazobactam (TZP) are increasingly used in practice,
the effect of infusion on the pharmacokinetic (PK) profile of TZP has not been widely …

Study Objective. To compare continuous versus intermittent administration of piperacillin‐
tazobactam with regard to clinical, microbiologic, and economic outcomes. Design …