A high-pressure liquid chromatography (HPLC) method with ultraviolet detection was
developed for the measurement of plasma free and total tazobactam and piperacillin. This …

Studies evaluating the outcomes of an extended-infusion (EI) piperacillin-tazobactam dosing
strategy in specific cohorts of critically ill patients are lacking. A retrospective, pre …

Piperacillin combined with tazobactam at a fixed concentration (4 μg/ml) and a ratio (8: 1)
was tested against 5029 aerobic isolates and 447 fastidious organisms, including …

Piperacillin/tazobactam is a β-lactam/β-lactamase inhibitor combination with a broad
spectrum of antibacterial activity against most Gram-positive and Gram-negative aerobic …

Background: Sustained low-efficiency dialysis (SLED), is increasingly being used in
intensive care units (ICUs) but studies informing drug dosing for such patients is lacking …

A high-performance liquid chromatographic (HPLC) method with ultraviolet (UV)
absorbance was developed for the analysis of piperacillin-tazobactam (tazocillin), in plasma …

Objectives: To characterize the population pharmacokinetics of piperacillin and tazobactam
in critically ill infants and children, in order to develop an evidence-based dosing regimen …

The pharmacokinetics of piperacillin and tazobactam were assessed after single-dose
administration to 47 infants and children. Study subjects ranging in age from 2 months to 12 …

Twenty-three generic intravenous piperacillin/tazobactam products were compared for in
vitro activity to the branded formulation (Zosyn®, Wyeth, Philadelphia, PA) by disk diffusion …

Outcomes of extended infusion piperacillin/tazobactam for documented Gram-negative infections -
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