The investigation of tissue penetration and distribution of antibiotics is of great importance,
since infections occur mostly in the tissues. The aim of this study was to investigate the …

Background: Complicated intra-abdominal infections (cIAI) are a common problem in
surgical practice. The effect of body mass index (BMI) on the outcome is poorly understood …

Tazobactam (Tazosyn®) is a novel β-lactamase inhibitor belonging to a class of penicillanic
acid sulfones. Tazobactam was developed to be used in combination with piperacillin …

Critical illness caused by burn and sepsis is associated with pathophysiologic changes that
may result in the alteration of pharmacokinetics (PK) of antibiotics. However, it is unclear if …

The increased prevalence of obesity presents challenges for clinicians aiming to provide
optimised antimicrobial dosing in the intensive care unit. Obesity is likely to exacerbate the …

Several factors influence the speed of development of antibacterial resistance, among which
is the amount of antibiotic consumption. During the 3-year period 1998-2000, the …

Twenty-five consecutive patients admitted to hospital with severe soft tissue infection were
entered into an open trial designed to evaluate safety and efficacy of the drug combination …

Objective: To describe a pharmacokinetic model of piperacillin concentrations in plasma and
subcutaneous tissue when administered by bolus dosing and continuous infusion in …

Continuous infusion (CI) piperacillin/tazobactam is frequently used to treat infections in very
elderly patients. This study aimed to conduct a population pharmacokinetic analysis of CI …

Polymicrobial infections are characterized by the presence of micro-organisms from more
than one group of bacteria. Empirical treatment of polymicrobial infections requires an agent …