Human carboxylesterases (hCEs) are key enzymes from the serine hydrolase superfamily.
Among all identified hCEs, human carboxylesterase 2 (hCE2) plays crucial roles in the …

In our search for natural human carboxylesterase 2 (hCE 2) inhibitors from natural products,
we investigated inhibitory effects and mechanisms of flavonoids (1–16) against hCE 2. The …

Human carboxylesterase 1 (hCE1), one of the most important serine hydrolases distributed
in liver and adipocytes, plays key roles in endobiotic homeostasis and xenobiotic …

Abstract Human carboxylesterase 1 (hCE1) is a key enzyme responsible for the hydrolysis of
a wide range of endogenous and xenobiotic esters, but the highly selective inhibitors …

Human carboxylesterase 2 (CES2), one of the most abundant hydrolases distributed in the
small intestine, has been validated as a key therapeutic target to ameliorate the intestinal …

Abstract Human carboxylesterase 2 (hCE2), one of the major carboxylesterases in the
human intestine and various tumour tissues, plays important roles in the oral bioavailability …

Mammalian carboxylesterases (CEs) are important serine hydrolases catalyzing the
hydrolysis of ester-or amide-containing compounds into the corresponding alcohols and …

Abstract Human Carboxylesterase 2A (hCES2A), one of the most important serine
hydrolases, plays crucial roles in the hydrolysis and the metabolic activation of a wide range …

Abstract Human carboxylesterase 1 (CES1), primarily expressed in the liver and adipocytes,
is responsible for the hydrolysis of endogenous esters (such as cholesteryl esters and …

Human carboxylesterase 2 (hCES2A) is a key target to ameliorate the intestinal toxicity
triggered by irinotecan that causes severe diarrhea in 50%–80% of patients receiving this …