The facile synthesis of biocompatible and nontoxic gene delivery vectors has been the focus
of research in recent years due to the high potential in treating genetic diseases. 2 …

Water-soluble polymers with equal positive and negative charges in the same monomer
unit, such as the phosphorylcholine group and other zwitterionic groups, exhibit promising …

We summarize the development and evaluation of new type of phospholipid polymers as a
solubilizer for poorly water-soluble compounds. That is, a water-soluble and amphiphilic …

A novel 2-(dimethylamino) ethyl methacrylate-block-2-(methacryloyloxyethyl
phosphorylcholine)(DMAEMA–MPC) diblock copolymer was synthesized and investigated …

In vivo gene delivery mediated by cationic lipids is often compromised by aggregation due to
complexation with proteins in the blood. To improve the stability of cationic lipid− DNA …

We examined a series of novel cationic MPC-based (2-methacryloyloxyethyl
phosphorylcholine) copolymers as vectors for gene delivery, with emphasis on the …

A new biodegradable polyphosphoester, poly {[(cholesteryl oxocarbonylamido ethyl) methyl
bis (ethylene) ammonium iodide] ethyl phosphate}(PCEP) was synthesized and investigated …

Synthetic chemical vectors have recently provided a versatile and robust platform for the
safe and efficient delivery of exogenous genes. Here, for the first time, a small series of N …

Purpose We tested polyplexes of a diblock polymer containing a pH-responsive,
endosomolytic core (dimethylaminoethyl methacrylate and butyl methacrylate; DB) and a …

Cationic polymers have been studied for nucleic acid delivery both in vitro and in vivo.
However, many polymer-based formulations suffer from lack of stability in biologic fluids due …