Cerebellar granule neurons undergo apoptosis when deprived of chronic depolarization;
serum deprivation has not been considered as a trigger of apoptosis in this culture. Here we …

We have investigated the role of reactive oxygen species (ROS) in cell death induced by
ischemia or application of the excitatory amino acid agonist, N-methyl-D-aspartate (NMDA) …

On exposure to glutamate, cultured rat cerebellar granule cells undergo a delayed Ca2+
deregulation (DCD), which precedes and predicts cell death. We have previously shown that …

When cultured cerebellar granule neurons (CGN) are transferred from 25 mM KCl (K25) to 5
mM KCl (K5) caspase‐3 and caspase‐8, but not caspase‐1 or caspase‐9, activities are …

Induction of chemical anoxia, using sodium azide in cerebellar granule cells maintained in
primary culture, was evaluated as an in vitro assay for screening of potential neuroprotective …

Glutamate kills sensitive neurons through several steps downstream to receptor activation:
increased free Ca2+ levels, activation of various enzymes and accumulation of reactive …

Cerebellar granule neurons can be readily maintained in culture if depolarized with high
concentrations of K+ or subtoxic concentrations of various excitatory amino acids. We now …

The relative contribution of sodium, chloride and calcium ions in the neuronal death induced
by glutamate is controversial. We have therefore reassessed the effects of extracellular ion …

Acutely dissociated rat cerebellar granule cell neurons were incubated with amyloid-β (1–
42) and studied by flow cytometry. Amyloid-β caused a dose-dependent loss of viability, as …

In cultured rat cerebellar granule cells, glutamate or N-methyl-d-aspartate (NMDA) activation
of the NMDA receptor caused a sustained increase in cytosolic Ca2+ levels ([Ca2+] i) …